دورية أكاديمية
A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations.
| العنوان: | A double blind study showing that two weeks of daily repetitive TMS over the left or right temporoparietal cortex reduces symptoms in patients with schizophrenia who are having treatment-refractory auditory hallucinations. |
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| المؤلفون: | Lee SH; Department of Psychiatry, Ilsanpaik Hospital, Inje University of Korea, Koyang, South Korea., Kim W, Chung YC, Jung KH, Bahk WM, Jun TY, Kim KS, George MS, Chae JH |
| المصدر: | Neuroscience letters [Neurosci Lett] 2005 Mar 16; Vol. 376 (3), pp. 177-81. Date of Electronic Publication: 2004 Dec 09. |
| نوع المنشور: | Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Scientific Publishers Ireland Country of Publication: Ireland NLM ID: 7600130 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0304-3940 (Print) Linking ISSN: 03043940 NLM ISO Abbreviation: Neurosci Lett Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Scientific Publishers Ireland Original Publication: Amsterdam, Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Electric Stimulation Therapy/*methods , Hallucinations/*therapy , Magnetics/*therapeutic use , Parietal Lobe/*physiopathology , Schizophrenia/*therapy , Temporal Lobe/*physiopathology, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Amnesia/physiopathology ; Cerebrovascular Circulation/physiology ; Dizziness/etiology ; Double-Blind Method ; Electric Stimulation Therapy/adverse effects ; Electric Stimulation Therapy/statistics & numerical data ; Electroencephalography ; Female ; Functional Laterality/physiology ; Hallucinations/etiology ; Hallucinations/physiopathology ; Headache/etiology ; Humans ; Magnetics/adverse effects ; Male ; Middle Aged ; Parietal Lobe/anatomy & histology ; Schizophrenia/physiopathology ; Temporal Lobe/anatomy & histology ; Treatment Outcome |
| مستخلص: | The aim of this study was to evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) on the left and right temporoparietal cortex compared with sham stimulation in schizophrenic patients with treatment-refractory auditory hallucinations (AH). Thirty-nine patients with schizophrenia with treatment-refractory AH were allocated randomly to one of three groups: daily left, right, and sham rTMS groups. rTMS was applied to the TP3 or 4 regions with the aid of the electroencephalography 10-20 international system at 1 Hz for 20 min per day for 10 treatment days. Symptoms were evaluated using the Auditory Hallucination Rating Scale (AHRS), the Positive and Negative Symptoms Scale (PANSS), the Clinical Global Impression--Severity (CGI-S), and Clinical Global Impression--Improvement (CGI-I) scale. For the time effect (within-subject comparison), there were significant changes in the frequency of AHs, positive symptoms of PANSS, and CGI-I. A between-group comparison revealed significant differences in the positive symptoms of PANSS, and CGI-I scores. Post hoc analysis revealed that both the right- and left-side rTMS treatment groups exhibited better CGI-I scores compared to the sham-stimulated group. This study suggests that 10 days of low-frequency rTMS applied daily for 20 min to either temporoparietal cortex significantly reduces the symptoms in patients with schizophrenia who are having refractory AH, but the left sided rTMS is not superior to right or sham rTMS. |
| التعليقات: | Comment in: Curr Psychiatry Rep. 2005 Jun;7(3):160-1. (PMID: 15935128) |
| تواريخ الأحداث: | Date Created: 20050222 Date Completed: 20050526 Latest Revision: 20220409 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.neulet.2004.11.048 |
| PMID: | 15721217 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0304-3940 |
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| DOI: | 10.1016/j.neulet.2004.11.048 |