دورية أكاديمية
[Detection of major gene on litter size in sheep].
| العنوان: | [Detection of major gene on litter size in sheep]. |
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| المؤلفون: | Wang QG; College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China. wangqigui@hotmail.com, Zhong FG, Li H, Wamg XH, Liu SR, Chen XJ, Gan SQ |
| المصدر: | Yi chuan = Hereditas [Yi Chuan] 2005 Jan; Vol. 27 (1), pp. 80-4. |
| نوع المنشور: | English Abstract; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Ke xue chu ban she Country of Publication: China NLM ID: 9436478 Publication Model: Print Cited Medium: Print ISSN: 0253-9772 (Print) Linking ISSN: 02539772 NLM ISO Abbreviation: Yi Chuan Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Beijing : Ke xue chu ban she, |
| مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Bone Morphogenetic Protein Receptors, Type I/*genetics , Litter Size/*genetics , Sheep/*genetics, Animals ; China ; Female ; Gene Frequency ; Genetic Markers ; Genotype ; Growth Differentiation Factor 9 ; Intercellular Signaling Peptides and Proteins/genetics ; Point Mutation ; Polymerase Chain Reaction ; Polymorphism, Restriction Fragment Length ; Sheep/classification ; Species Specificity |
| مستخلص: | The current study was designed to detect SNPs within BMP15 and BMPR-IB gene and investigate the effect of the genes on sheep litter size. Four sheep lines, HU-Yang, Chinese Merino monotocous, Chinese Merino multiparous for wool production and Chinese Merino multiparous for mutton production, were used in this study. Litter sizes were recorded for each ewe in the four lines. Primers for BMP15 and BMPR-IB gene were designed from database sheep sequence and polymorphisms were detected by PCR-RFLP method. The results showed that there was no polymorphism with BMP15 gene among the four lines, and there was an A / G SNP with BMPR-IB gene at base 746 among the four lines. Three types of genotype (BB, B+ and ++), based on A / G locus, were found within each line. The frequencies of genotypes were significantly different among the lines (P<0.001), with BB genotype primarily existing in HU-Yang, ++ genotype in Chinese Merino monotocous line, and B+ genotype in Chinnese Merino multiparous lines. The A / G mutation influence significantly the sheep litter sizes, and the BB and B+ ewes had significant higher litter sizes than ++ ewes. The results of present study showed simultaneously that the genotype of BMPR-IB was a perfect predictor of the sheep litter sizes. These results intensively indicated that BMPR-IB is a major gene to affect litter size in sheep, and could be used as the molecular genetic marker to select litter size in sheep. |
| المشرفين على المادة: | 0 (Genetic Markers) 0 (Growth Differentiation Factor 9) 0 (Intercellular Signaling Peptides and Proteins) EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type I) |
| تواريخ الأحداث: | Date Created: 20050226 Date Completed: 20060104 Latest Revision: 20161020 |
| رمز التحديث: | 20240628 |
| PMID: | 15730965 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0253-9772 |
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