دورية أكاديمية
Prolonged HCG action affects angiogenic substances and improves follicular maturation, oocyte quality and fertilization competence in patients with polycystic ovarian syndrome.
| العنوان: | Prolonged HCG action affects angiogenic substances and improves follicular maturation, oocyte quality and fertilization competence in patients with polycystic ovarian syndrome. |
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| المؤلفون: | Bokal EV; Reproductive Unit, Department of Obstetrics and Gynaecology, University Medical Centre Ljubljana, Slajmerjeva 3, SI-1000 Ljubljana, Slovenia. eda.bokal@guest.arnes.si, Vrtovec HM, Virant Klun I, Verdenik I |
| المصدر: | Human reproduction (Oxford, England) [Hum Reprod] 2005 Jun; Vol. 20 (6), pp. 1562-8. Date of Electronic Publication: 2005 Feb 25. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 8701199 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0268-1161 (Print) Linking ISSN: 02681161 NLM ISO Abbreviation: Hum Reprod Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford, UK : Oxford University Press Original Publication: Oxford ; Washington, DC : Published for the European Society of Human Reproduction and Embryology by IRL Press, [c1986- |
| مواضيع طبية MeSH: | Angiogenic Proteins/*metabolism , Chorionic Gonadotropin/*administration & dosage , Fertilization in Vitro/*methods , Oocytes/*physiology , Polycystic Ovary Syndrome/*drug therapy, Adult ; Chorionic Gonadotropin/therapeutic use ; Embryo, Mammalian/physiology ; Estradiol ; Female ; Follicular Fluid/metabolism ; Humans ; Infertility, Female/therapy ; Oocytes/drug effects ; Ovarian Follicle/drug effects ; Ovarian Follicle/physiology ; Polycystic Ovary Syndrome/complications ; Pregnancy ; Renin/drug effects ; Renin/metabolism ; Sperm Injections, Intracytoplasmic ; Vascular Endothelial Growth Factor A/drug effects ; Vascular Endothelial Growth Factor A/metabolism |
| مستخلص: | Background: The aim of this study was to determine whether, in polycystic ovarian syndrome (PCOS) patients, HCG action prolonged for 4 h improves the action of angiogenic substances [ovarian renin angiotensin system and vascular endothelial growth factor (VEGF)], and consequently follicular maturation, oocyte quality and oocyte fertilization competence. Methods: In this prospective study 20 patients with PCOS undergoing IVF were included. Oocyte retrieval was carried out either 34 or 38 h after HCG administration. Each follicle was analysed for prorenin, active renin, VEGF and estradiol. Oocytes were evaluated for quality (mature, immature, degenerated oocytes), as were the embryos (low or high). Results: In the HCG +38 h group there were 245 follicles, and in the HCG +34 h group 240 follicles. In the HCG +38 h group, log active renin was lower (2.78 +/- 0.20 versus 2.91 +/- 0.25; P < 0.001) and VEGF higher (2276.0 +/- 790.1 versus 1946.6 +/- 954.5 pg/ml; P < 0.001). The odds ratio for obtaining oocytes from follicles was 1.6 [95% confidence interval (CI) 1.1-2.6; P = 0.02], and for developing high quality embryos 7.6 (95% CI 2.8-20.9; P < 0.001) in favour of the HCG +38 h group. Conclusions: Follicular maturation and oocyte quality are related to the intrafollicular influences of active renin and VEGF in a time-dependent manner after HCG administration, whereas fertilization competence is related to VEGF only. |
| المشرفين على المادة: | 0 (Angiogenic Proteins) 0 (Chorionic Gonadotropin) 0 (Vascular Endothelial Growth Factor A) 4TI98Z838E (Estradiol) EC 3.4.23.15 (Renin) |
| تواريخ الأحداث: | Date Created: 20050301 Date Completed: 20050929 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1093/humrep/deh789 |
| PMID: | 15734758 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0268-1161 |
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| DOI: | 10.1093/humrep/deh789 |