دورية أكاديمية
[A study of the expression of Fas after fluid percussion brain injury in rats].
| العنوان: | [A study of the expression of Fas after fluid percussion brain injury in rats]. |
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| المؤلفون: | Pan HF; West China College of Basic Medicine and Forensic Medicine of Sichuan University, Chengdu 610041, China., Wang Y, Chen XG, Yang J, Li L, Peng Q, Wang W, Liu M |
| المصدر: | Fa yi xue za zhi [Fa Yi Xue Za Zhi] 2004; Vol. 20 (4), pp. 205-7. |
| نوع المنشور: | Journal Article |
| اللغة: | Chinese |
| بيانات الدورية: | Publisher: Si fa bu si fa jian ding ke xue yan jiu yuan Country of Publication: China NLM ID: 9426151 Publication Model: Print Cited Medium: Print ISSN: 1004-5619 (Print) Linking ISSN: 10045619 NLM ISO Abbreviation: Fa Yi Xue Za Zhi Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Shanghai : Si fa bu si fa jian ding ke xue yan jiu yuan Original Publication: Shanghai : Si fa bu si fa jian ding ke xue ji shu yan jiu suo, |
| مواضيع طبية MeSH: | Brain/*metabolism , Brain Injuries/*diagnosis , Membrane Glycoproteins/*biosynthesis , Tumor Necrosis Factors/*biosynthesis, Animals ; Apoptosis ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Fas Ligand Protein ; Image Processing, Computer-Assisted ; Immunohistochemistry ; Male ; Rats ; Rats, Wistar ; Time Factors |
| مستخلص: | Objective: To study the pathologic diagnosis and the injury time estimation in light closed encephalon injury. Methods: Mice were hurt by fluid percussion, and were killed at 15, 30 min, 1, 3 , 6, 12 h, 1, 4, 7, 14 d respectively after injury. The expression of Fas-L in the cerebral cortex, thalamus, and hippocampi was detected by immunohistochemistry and the results were assessed by image analysis system. Results: It is showed that the expression of Fas-L could be detected in 1 h after injury, and increased significantly in three hours, and it reached apex 12 h after injury, and decreased gradually four days after injury, and returned normal 14 days after injury. Conclusion: This research demonstrated that Fas-L mediated apoptosis appeared not only around brain trauma but also in the brain tissue far away from the traumatic area. It indicted that the expression of Fas-L is a useful target for diagnosis of early brain injury; the regularity of Fas-L expression could be used as one of indication to date the time of brain injury. |
| المشرفين على المادة: | 0 (Fas Ligand Protein) 0 (Faslg protein, rat) 0 (Membrane Glycoproteins) 0 (Tumor Necrosis Factors) |
| تواريخ الأحداث: | Date Created: 20050309 Date Completed: 20060407 Latest Revision: 20200914 |
| رمز التحديث: | 20231215 |
| PMID: | 15751654 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1004-5619 |
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