دورية أكاديمية
Calling for help is independently modulated by brain systems underlying goal-directed behavior and threat perception.
| العنوان: | Calling for help is independently modulated by brain systems underlying goal-directed behavior and threat perception. |
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| المؤلفون: | Fox AS; Waisman Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin, Madison, WI 53706, USA., Oakes TR, Shelton SE, Converse AK, Davidson RJ, Kalin NH |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Mar 15; Vol. 102 (11), pp. 4176-9. Date of Electronic Publication: 2005 Mar 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Animal Communication*, Behavior, Animal/*physiology , Brain/*physiology , Perception/*physiology, Animals ; Macaca mulatta ; Male ; Positron-Emission Tomography |
| مستخلص: | In primates, during times of need, calling for help is a universal experience. Calling for help recruits social support and promotes survival. However, calling for help also can attract predators, and it is adaptive to inhibit calls for help when a potential threat is perceived. Based on this, we hypothesized that individual differences in calling for help would be related to the activity of brain systems that mediate goal-directed behavior and the detection of threat. By using high-resolution positron emission tomography in rhesus monkeys undergoing social separation, we demonstrate that increased [18F]-fluoro-2-deoxy-D-glucose uptake in the right dorsolateral prefrontal cortex and decreased uptake in the amygdala independently predict individual differences in calling for help. When taken together, these two regions account for 76% of the variance in calling for help. This result suggests that the drive for affiliation and the perception of threat determine the intensity of an individual's behavior during separation. These findings in monkeys are relevant to humans and provide a conceptual neural framework to understand individual differences in how primates behave when in need of social support. |
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| معلومات مُعتمدة: | MH69315 United States MH NIMH NIH HHS; MH46729 United States MH NIMH NIH HHS; R01 MH046729 United States MH NIMH NIH HHS; P50 MH052354 United States MH NIMH NIH HHS; P50 MH069315 United States MH NIMH NIH HHS; MH52354 United States MH NIMH NIH HHS |
| تواريخ الأحداث: | Date Created: 20050309 Date Completed: 20050509 Latest Revision: 20240315 |
| رمز التحديث: | 20240315 |
| مُعرف محوري في PubMed: | PMC554810 |
| DOI: | 10.1073/pnas.0409470102 |
| PMID: | 15753316 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0027-8424 |
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| DOI: | 10.1073/pnas.0409470102 |