دورية أكاديمية
o-Aminoazotoluene does induce the enzymes of its own mutagenic activation in mouse liver.
| العنوان: | o-Aminoazotoluene does induce the enzymes of its own mutagenic activation in mouse liver. |
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| المؤلفون: | Mikhailova ON; Laboratory of Molecular Mechanisms of Carcinogenesis, Institute of Molecular Biology and Biophysics, Timakov Street 2, Novosibirsk 630117, Russia. pharmacogenomics@ngs.ru, Vasyunina EA, Ovchinnikova LP, Gulyaeva LF, Timofeeva OA, Filipenko ML, Kaledin VI |
| المصدر: | Toxicology [Toxicology] 2005 Jul 01; Vol. 211 (1-2), pp. 132-8. Date of Electronic Publication: 2005 Apr 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0361055 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0300-483X (Print) Linking ISSN: 0300483X NLM ISO Abbreviation: Toxicology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam. Elsevier/North-Holland. |
| مواضيع طبية MeSH: | Enzyme Induction/*drug effects , Liver/*enzymology , Mutagens/*metabolism , Mutagens/*toxicity , o-Aminoazotoluene/*pharmacology, Animals ; Benzo(a)pyrene/metabolism ; Biotransformation/drug effects ; Chlorodiphenyl (54% Chlorine)/pharmacology ; Cytochrome P-450 CYP1A1/biosynthesis ; Cytochrome P-450 CYP1A2/biosynthesis ; DNA, Complementary/biosynthesis ; DNA, Complementary/isolation & purification ; Hydroxylation ; Liver/drug effects ; Male ; Mice ; Mice, Inbred C57BL ; Mutagenicity Tests ; RNA/biosynthesis ; RNA/isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction ; Subcellular Fractions/drug effects ; Subcellular Fractions/enzymology ; o-Aminoazotoluene/metabolism ; o-Aminoazotoluene/toxicity |
| مستخلص: | The objective of this study was to investigate the CYP1A1 and CYP1A2 mRNAs and enzyme activities in mouse liver during induction with o-aminoazotoluene (OAT) as well as the capability of the hepatic S9-fraction from OAT-treated mice to induce its own activation to mutagens in the Ames test using S. typhymurium strain TA98. The data obtained indicate that when used at appropriate doses, OAT is a PAH-type inducer of mouse hepatic microsomal monooxygenases, which activity is not less than that of the known inducer 3,4-benzo[alpha]pyrene. In the absence of S9-fraction enzymes no OAT-mediated mutagenicity was observed in the Ames test. In the presence of the S9-fraction from OAT-pretreated mice, OAT induced as high revertant numbers, as it did in the presence of the S9 fraction from the liver of Aroclor 1254-treated mice. Thus, OAT does induce the enzymes of its own mutagenic activation in mouse liver. |
| المشرفين على المادة: | 0 (DNA, Complementary) 0 (Mutagens) 11097-69-1 (Chlorodiphenyl (54% Chlorine)) 3417WMA06D (Benzo(a)pyrene) 63231-63-0 (RNA) EC 1.14.14.1 (Cytochrome P-450 CYP1A1) EC 1.14.14.1 (Cytochrome P-450 CYP1A2) QHZ900P7ZA (o-Aminoazotoluene) |
| تواريخ الأحداث: | Date Created: 20050503 Date Completed: 20050620 Latest Revision: 20131121 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.tox.2005.03.006 |
| PMID: | 15863256 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0300-483X |
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| DOI: | 10.1016/j.tox.2005.03.006 |