دورية أكاديمية
Galanin and alcohol dependence: neurobehavioral research.
| العنوان: | Galanin and alcohol dependence: neurobehavioral research. |
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| المؤلفون: | Lewis MJ; Department of Psychology, Princeton University, Green Hall, Princeton, NJ 08544, USA., Rada P, Johnson DF, Avena NM, Leibowitz SF, Hoebel BG |
| المصدر: | Neuropeptides [Neuropeptides] 2005 Jun; Vol. 39 (3), pp. 317-21. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8103156 Publication Model: Print Cited Medium: Print ISSN: 0143-4179 (Print) Linking ISSN: 01434179 NLM ISO Abbreviation: Neuropeptides Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2002- : Amsterdam : Elsevier Original Publication: Edinburgh ; New York : Churchill Livingstone, c1980- |
| مواضيع طبية MeSH: | Alcohol Drinking/*physiopathology , Behavior, Animal/*physiology , Galanin/*physiology, Animals ; Behavior, Animal/drug effects ; Galanin/pharmacology |
| مستخلص: | It is known that microinjection of galanin (GAL) intraventricularly or in specific hypothalamic sites increases food consumption and, conversely, the intake of food increases the expression of GAL in hypothalamic sites. Ethanol (EtOH) is a calorie-rich food as well as a drug of abuse. The research reviewed here shows that GAL may play a similar role in alcohol intake. First, experiments in which GAL was microinjected into the third ventricle or the paraventricular nucleus (PVN) showed increases in EtOH consumption. The increase in EtOH consumption occurred during both the light and dark cycles after GAL injection in the third ventricle in rats with limited EtOH access. Injection of GAL did not increase food intake in rats that had been chronically drinking alcohol. GAL receptor blockade reversed these increases. Microinjection of GAL directly into the PVN also increased ad libitum EtOH intake and blockade of these receptors in the PVN inhibited ad libitum EtOH consumption. Secondly, rats administered EtOH showed increases in GAL in the PVN and related hypothalamic sites. EtOH injection and voluntary intake, both ad libitum and limited access, increased GAL gene and peptide expression in the PVN consistently across administration procedures. These experiments show that GAL injection increases alcohol intake and that the intake of alcohol increases GAL, suggesting a positive feedback relationship between alcohol intake and specific hypothalamic GAL systems. Such a relationship may contribute to the motivation to consume excessive alcoholic beverages and the development of alcohol dependence. |
| Number of References: | 16 |
| معلومات مُعتمدة: | AA012882 United States AA NIAAA NIH HHS; AA014074 United States AA NIAAA NIH HHS |
| المشرفين على المادة: | 88813-36-9 (Galanin) |
| تواريخ الأحداث: | Date Created: 20050512 Date Completed: 20050913 Latest Revision: 20071114 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.npep.2004.12.027 |
| PMID: | 15885773 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0143-4179 |
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| DOI: | 10.1016/j.npep.2004.12.027 |