دورية أكاديمية
Potential of adult mammalian lumbosacral spinal cord to execute and acquire improved locomotion in the absence of supraspinal input.
| العنوان: | Potential of adult mammalian lumbosacral spinal cord to execute and acquire improved locomotion in the absence of supraspinal input. |
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| المؤلفون: | Edgerton VR; Brain Research Institute, University of California at Los Angeles., Roy RR, Hodgson JA, Prober RJ, de Guzman CP, de Leon R |
| المصدر: | Journal of neurotrauma [J Neurotrauma] 1992 Mar; Vol. 9 Suppl 1, pp. S119-28. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert Country of Publication: United States NLM ID: 8811626 Publication Model: Print Cited Medium: Print ISSN: 0897-7151 (Print) Linking ISSN: 08977151 NLM ISO Abbreviation: J Neurotrauma Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Larchmont, NY : Mary Ann Liebert Original Publication: New York, NY : Mary Ann Liebert, c1988- |
| مواضيع طبية MeSH: | Locomotion/*physiology , Motor Activity/*physiology , Spinal Cord/*physiology , Spinal Cord Injuries/*physiopathology, Animals ; Cats ; Clonidine/pharmacology ; Electromyography ; Female ; Muscles/drug effects ; Muscles/physiology ; Spinal Cord/physiopathology ; Time Factors |
| مستخلص: | The neural circuitry of the lumbar spinal cord can generate alternating extension and flexion of the hindlimbs. The hindlimbs of adult cats with complete transection of the spinal cord at a low thoracic level (T12-T13) can perform full weight-supporting locomotion on a treadmill belt moving at a range of speeds. Some limitations in the locomotor capacity can be associated with a deficit in the recruitment level of the fast extensors during the stance phase and the flexors during the swing phase of a step cycle. The level of locomotor performance, however, can be enhanced by daily training on a treadmill while emphasizing full weight-support stepping and by providing appropriately timed sensory stimulation, loading, and/or pharmacologic stimulation of the hindlimb neuromuscular apparatus. Furthermore, there appears to be an interactive effect of these interventions. For example, the maximum treadmill speed that a spinal adult cat can attain and maintain is significantly improved with daily full weight-supporting treadmill training, but progressive recruitment of fast extensors becomes apparent only when the hindlimbs are loaded by gently pulling down on the tail during the stepping. Stimulation of the sural nerve at the initiation of the flexion phase of the step cycle can likewise markedly improve the locomotor capability. Administration of clonidine, in particular in combination with an elevated load, resulted in the most distinct and consistent alternating bursts of electromyographic activity during spinal stepping. These data indicate that the spinal cord has the ability to execute alternating activation of the extensor and flexor musculature of the hindlimbs (stepping) and that this ability can be improved by several interventions such as training, sensory stimulation, and use of some pharmacologic agents. Thus, it appears that the spinal cord, without supraspinal input, is highly plastic and has the potential to "learn," that is, to acquire and improve its ability to execute full weight-supporting locomotion on a treadmill belt. |
| معلومات مُعتمدة: | NS16333 United States NS NINDS NIH HHS |
| فهرسة مساهمة: | Investigator: VR Edgerton, U CA, Los Angeles Keywords: NASA Discipline Musculoskeletal; Non-NASA Center |
| المشرفين على المادة: | MN3L5RMN02 (Clonidine) |
| تواريخ الأحداث: | Date Created: 19920301 Date Completed: 19920622 Latest Revision: 20131121 |
| رمز التحديث: | 20240627 |
| PMID: | 1588602 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0897-7151 |
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