دورية أكاديمية
Genetic variations of the dihydrofolate reductase gene of Plasmodium vivax in Mandalay Division, Myanmar.
| العنوان: | Genetic variations of the dihydrofolate reductase gene of Plasmodium vivax in Mandalay Division, Myanmar. |
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| المؤلفون: | Na BK; Department of Molecular Parasitology, Center for Molecular Medicine, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon 440-746, Korea., Lee HW, Moon SU, In TS, Lin K, Maung M, Chung GT, Lee JK, Kim TS, Kong Y |
| المصدر: | Parasitology research [Parasitol Res] 2005 Jul; Vol. 96 (5), pp. 321-5. Date of Electronic Publication: 2005 May 28. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8703571 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0932-0113 (Print) Linking ISSN: 09320113 NLM ISO Abbreviation: Parasitol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Berlin : Springer International, c1987- |
| مواضيع طبية MeSH: | Genetic Variation*, Plasmodium vivax/*genetics , Tetrahydrofolate Dehydrogenase/*genetics, Amino Acid Sequence ; Animals ; Codon ; Humans ; Malaria, Vivax/parasitology ; Molecular Sequence Data ; Myanmar ; Sequence Alignment |
| مستخلص: | Dihydrofolate reductase (DHFR; EC1.5.1.3) is a known target enzyme for antifolate agents, which are used as alternative chemotherapeutics for chloroquine-resistant malaria. Mutations in the dhfr gene of Plasmodium vivax are thought to be associated with resistance to the antifolate drugs. In this study, we have analyzed genetic variations in the dhfr genes of clinical isolates of P. vivax (n=21) in Myanmar, to monitor antifolate resistance in this country. Sequence variations within the entire dhfr gene were highly restricted to codons from 57 to 117, and the GGDN tandem repeat region. Double (S58R and S117N/T) or quadruple mutations (F57L/I, S58R, T61M, and S117N/T), which may be closely related to the drug resistance, were recognized in most of the isolates (20/21 cases). Our results suggest that antifolate-resistant P. vivax is becoming widespread in Myanmar, as it also is in the neighboring countries in Southeast Asia. It appears that the drug resistance situation may be worsening in the country. |
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| المشرفين على المادة: | 0 (Codon) EC 1.5.1.3 (Tetrahydrofolate Dehydrogenase) |
| تواريخ الأحداث: | Date Created: 20050601 Date Completed: 20050928 Latest Revision: 20181113 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00436-005-1364-0 |
| PMID: | 15924223 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0932-0113 |
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| DOI: | 10.1007/s00436-005-1364-0 |