دورية أكاديمية
Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy.
| العنوان: | Polymorphisms of the renin-angiotensin system genes in Brazilian patients with lupus nephropathy. |
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| المؤلفون: | Sprovieri SR; Department of Internal Medicine, Faculty of Medical Sciences, Santa Casa de São Paulo, Brazil. luvieri@uol.com.br, Sens YA |
| المصدر: | Lupus [Lupus] 2005; Vol. 14 (5), pp. 356-62. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publications Country of Publication: England NLM ID: 9204265 Publication Model: Print Cited Medium: Print ISSN: 0961-2033 (Print) Linking ISSN: 09612033 NLM ISO Abbreviation: Lupus Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : SAGE Publications Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical Division, Macmillan Press Ltd., c1991- |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease* , Polymorphism, Genetic*, Angiotensinogen/*genetics , Lupus Nephritis/*genetics , Peptidyl-Dipeptidase A/*genetics , Receptor, Angiotensin, Type 1/*genetics , Renin-Angiotensin System/*genetics, Adult ; Brazil ; Case-Control Studies ; Disease Progression ; Female ; Gene Frequency ; Genotype ; Humans ; Hypertension/complications ; Hypertension/genetics ; Kidney Failure, Chronic/etiology ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/genetics ; Lupus Nephritis/ethnology ; Male ; Middle Aged |
| مستخلص: | Genetic polymorphisms of the renin-angiotensin system (RAS) has been associated with cardiovascular events and the progression of nephropathy in several diseases. The objective of this study was to evaluate a possible association of the genetic polymorphisms of RAS with the development and/or progression of lupus nephritis in a Brazilian population. Seventy-five SLE patients with lupus nephropathy (LN group) were compared to 72 SLE patients without LN (SLE group) and 65 healthy individuals (CONTROL group), of sex and ethnic matched, in a Brazilian population sample. Mean global follow-up was 9 +/- 6 years for lupus without nephropathy and 11 +/- 7 years for lupus nephropathy. Following the extraction of genomic DNA from the leukocytes in the peripheral blood, angiotensin converting enzyme (ACE I/D), angiotensinogen (AGT M(235)T) and angiotensin II type 1 receptor (AGTR1 A(1166)C) genotypes were determined by the polymerase chain reaction. No significant difference of ACE, AGT and AGTR1 genotypes distribution between groups was observed in this study. There was no significant association between the variables of the RAS genotypes and the presence of hypertension in SLE. However, an increased frequency ofDD genotype (ACE I/D) was observed in SLE patients with LN who progressed to CRF compared to healthy controls (DD 60%, DI 26.7%, II 13.3% versus 27.7%, 60% and 12.3%, respectively; chi2 = 6.299, P = 0.0429). In the population studied, there was no influence of the RAS genetic polymorphisms in the development of lupus nephropathy, but the progression to CRF was associated with ACE DD polymorphism. |
| المشرفين على المادة: | 0 (Receptor, Angiotensin, Type 1) 11002-13-4 (Angiotensinogen) EC 3.4.15.1 (Peptidyl-Dipeptidase A) |
| تواريخ الأحداث: | Date Created: 20050607 Date Completed: 20050922 Latest Revision: 20170214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1191/0961203305lu2093oa |
| PMID: | 15934435 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0961-2033 |
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| DOI: | 10.1191/0961203305lu2093oa |