دورية أكاديمية
Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study.
| العنوان: | Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. |
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| المؤلفون: | Zambelli-Weiner A; Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA., Ehrlich E, Stockton ML, Grant AV, Zhang S, Levett PN, Beaty TH, Barnes KC |
| المصدر: | The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2005 Jun; Vol. 115 (6), pp. 1203-9. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print Cited Medium: Print ISSN: 0091-6749 (Print) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: St Louis, Mosby. |
| مواضيع طبية MeSH: | Polymorphism, Genetic*, Asthma/*etiology , Dust/*analysis , Endotoxins/*analysis , Lipopolysaccharide Receptors/*genetics, Adult ; Asthma/genetics ; Barbados ; Case-Control Studies ; Family Characteristics ; Female ; Genotype ; Humans ; Male |
| مستخلص: | Background: Both a functional promoter polymorphism in the gene encoding CD14 (C-260T) and exposure to endotoxin are believed to play key roles in modulating the immune response and expression of atopic disease. Objective: We aimed to evaluate the role of the CD14 C-260T polymorphism in a population of African descent and to test for interaction between this genotype and house dust endotoxin (HDE) exposure on atopic phenotypes. Methods: Asthmatic probands and their families were recruited as part of the Barbados Asthma Genetics Study. The C-260T polymorphism and two additional CD14 promoter markers (G-1461T, C-1721T) were genotyped. Endotoxin was measured in house dust samples. Results: Using a Family-Based Association Test, the C-260T allele appeared to be protective against asthma ( z = -2.444; P = .015) and asthma severity ( z = -2.615; P = .009) under a recessive model. No significant associations were observed for the G-1461T and C-1721T markers both individually and in haplotypes. In a case-control analysis, the CD14 TT genotype was found to reduce risk of asthma compared with the CD14 CC/CT genotypes (odds ratio [OR], 0.26; 95% CI, 0.14-0.49) and was associated with lower asthma severity scores ( P < .002). The TT genotype might protect against asthma for individuals with low HDE (OR, 0.09; 95% CI, 0.03-0.24), but may be a risk factor for individuals with high HDE (OR, 11.66; 95% CI, 1.03-131.7), suggesting a gene-environment interaction. Conclusion: These data suggest that the CD14-260 polymorphism may play a role in controlling risk to atopic disease and underscore the importance of incorporating key environmental exposures into studies of genetic risk factors. |
| معلومات مُعتمدة: | AI 20059 United States AI NIAID NIH HHS; T32 ES 07141 United States ES NIEHS NIH HHS |
| المشرفين على المادة: | 0 (Dust) 0 (Endotoxins) 0 (Lipopolysaccharide Receptors) |
| تواريخ الأحداث: | Date Created: 20050609 Date Completed: 20050802 Latest Revision: 20171116 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jaci.2005.03.001 |
| PMID: | 15940135 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0091-6749 |
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| DOI: | 10.1016/j.jaci.2005.03.001 |