دورية أكاديمية
Subretinal neovascular membranes complicating uveitis: frequency, treatments, and visual outcome.
| العنوان: | Subretinal neovascular membranes complicating uveitis: frequency, treatments, and visual outcome. |
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| المؤلفون: | Perentes Y; Inflammatory Eye Diseases, La Source Eye Center, Lausanne, Switzerland., Van Tran T, Sickenberg M, Herbort CP |
| المصدر: | Ocular immunology and inflammation [Ocul Immunol Inflamm] 2005 Apr-Jun; Vol. 13 (2-3), pp. 219-24. |
| نوع المنشور: | Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312169 Publication Model: Print Cited Medium: Print ISSN: 0927-3948 (Print) Linking ISSN: 09273948 NLM ISO Abbreviation: Ocul Immunol Inflamm Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Buren, The Netherlands : Aeolus Press, c1993- |
| مواضيع طبية MeSH: | Visual Acuity*/physiology, Glucocorticoids/*therapeutic use , Hyperthermia, Induced/*methods , Laser Coagulation/*methods , Photochemotherapy/*methods , Retinal Neovascularization/*etiology , Uveitis/*complications, Adolescent ; Adult ; Aged ; Disease Progression ; Female ; Fluorescein Angiography ; Follow-Up Studies ; Fundus Oculi ; Humans ; Incidence ; Male ; Middle Aged ; Retina/pathology ; Retinal Neovascularization/epidemiology ; Retinal Neovascularization/therapy ; Retrospective Studies ; Switzerland/epidemiology ; Treatment Outcome ; Uveitis/diagnosis |
| مستخلص: | Purpose: Retrospective evaluation in a uveitic population of subretinal neovascular membranes (SRNMs), their occurrence, visual impact, and outcome in differently treated subgroups of patients. Methods: Medical records of patients were reviewed and cases with SRNM (n = 12) identified. Intraocular inflammation was classified according to vitreous examination records as high (2+ cells), low (1/2+ to 1+ cells), or inactive (0 cells). Visual outcome was considered to be +VA (same or gain of one or more Snellen lines) or -VA (loss of Snellen lines). In nine cases, treatment consisted of the oral administration of high doses of corticosteroids (CST) for one month, tapered down in favorable situations (+VA or SRNM angiographic regression) or maintained at half the dose in unfavorable situations (-VA or SRNM angiographic progression) while additional laser therapies, including photodynamic therapy (PDT), transpupillary thermotherapy (TTT), or argon laser therapy (CLT)), were performed in some of the cases. The above treatment scheme was not applied in three cases (pre-PDT period; undiagnosed underlying uveitis treated without CST). Results: Twelve out of 648 patients (1.9%) with uveitis developed SRNM. The mean visual impact was 4.5 Snellen lines and mean follow-up time was 19.5 months. Two patients with high intraocular inflammation had a favorable visual outcome with CST alone. Eight patients with low intraocular inflammation had a favorable visual outcome with CST alone in three cases, with additional laser therapy in four cases (PDT in 3 cases and TTT in 1 case), and exclusively with PDT in one case (undiagnosed uveitis). Two patients with no intraocular inflammation had unfavorable visual outcome with CST alone (no PDT/TTT available). Conclusion: SRNMs occurred as a rare complication of uveitis. Their visual outcome was relatively favorable. Although high doses of CST seem to be the first step in the management of SRNMs, alternative laser treatments should be considered early, especially in cases of absence or low intraocular inflammation. |
| المشرفين على المادة: | 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20050716 Date Completed: 20050927 Latest Revision: 20061115 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/09273940490518883 |
| PMID: | 16019682 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0927-3948 |
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| DOI: | 10.1080/09273940490518883 |