دورية أكاديمية
أعرض في EDS

Cerebral aspergillosis due to Aspergillus fumigatus in AIDS patient: first culture-proven case reported in Brazil.

التفاصيل البيبلوغرافية
العنوان: Cerebral aspergillosis due to Aspergillus fumigatus in AIDS patient: first culture-proven case reported in Brazil.
المؤلفون: Vidal JE; Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil. jbermudez@emilioribas.sp.gov.br, Dauar RF, Melhem MS, Szeszs W, Pukinskas SR, Coelho JF, Lins DL, Costa SF, Penalva de Oliveira AC, Lacaz Cda S
المصدر: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2005 May-Jun; Vol. 47 (3), pp. 161-5. Date of Electronic Publication: 2005 Jul 12.
نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0036-4665 (Print) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Sao Paulo : Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo
مواضيع طبية MeSH: AIDS-Related Opportunistic Infections/*microbiology , Aspergillus fumigatus/*isolation & purification , Brain Abscess/*microbiology , Neuroaspergillosis/*diagnosis, AIDS-Related Opportunistic Infections/diagnosis ; AIDS-Related Opportunistic Infections/drug therapy ; Adult ; Amphotericin B/therapeutic use ; Antifungal Agents/therapeutic use ; Brain Abscess/diagnosis ; Brain Abscess/drug therapy ; Brazil ; Deoxycholic Acid/therapeutic use ; Drug Combinations ; Fatal Outcome ; Humans ; Male ; Neuroaspergillosis/drug therapy
مستخلص: Cerebral aspergillosis is a rare cause of brain expansive lesion in AIDS patients. We report the first culture-proven case of brain abscess due to Aspergillus fumigatus in a Brazilian AIDS patient. The patient, a 26 year-old male with human immunodeficiency virus (HIV) infection and history of pulmonary tuberculosis and cerebral toxoplasmosis, had fever, cough, dyspnea, and two episodes of seizures. The brain computerized tomography (CT) showed a bi-parietal and parasagittal hypodense lesion with peripheral enhancement, and significant mass effect. There was started anti-Toxoplasma treatment. Three weeks later, the patient presented mental confusion, and a new brain CT evidenced increase in the lesion. He underwent brain biopsy, draining 10 mL of purulent material. The direct mycological examination revealed septated and hyaline hyphae. There was started amphotericin B deoxycholate. The culture of the material demonstrated presence of the Aspergillus fumigatus. The following two months, the patient was submitted to three surgeries, with insertion of drainage catheter and administration of amphotericin B intralesional. Three months after hospital admission, his neurological condition suffered discrete changes. However, he died due to intrahospital pneumonia. Brain abscess caused by Aspergillus fumigatus must be considered in the differential diagnosis of the brain expansive lesions in AIDS patients in Brazil.
المشرفين على المادة: 0 (Antifungal Agents)
0 (Drug Combinations)
005990WHZZ (Deoxycholic Acid)
7XU7A7DROE (Amphotericin B)
87687-70-5 (amphotericin B, deoxycholate drug combination)
تواريخ الأحداث: Date Created: 20050716 Date Completed: 20051103 Latest Revision: 20190608
رمز التحديث: 20240628
DOI: 10.1590/s0036-46652005000300009
PMID: 16021291
قاعدة البيانات: MEDLINE
الوصف
تدمد:0036-4665
DOI:10.1590/s0036-46652005000300009