دورية أكاديمية
Determination of L-365,260, a new cholecystokinin receptor (CCK-B) antagonist, in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.
| العنوان: | Determination of L-365,260, a new cholecystokinin receptor (CCK-B) antagonist, in plasma by liquid chromatography/atmospheric pressure chemical ionization mass spectrometry. |
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| المؤلفون: | Gilbert JD; Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486., Hand EL, Yuan AS, Olah TV, Covey TR |
| المصدر: | Biological mass spectrometry [Biol Mass Spectrom] 1992 Feb; Vol. 21 (2), pp. 63-8. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley Country of Publication: England NLM ID: 9102982 Publication Model: Print Cited Medium: Print ISSN: 1052-9306 (Print) Linking ISSN: 10529306 NLM ISO Abbreviation: Biol Mass Spectrom Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Chichester, Sussex, England : Wiley, c1991-1994. |
| مواضيع طبية MeSH: | Phenylurea Compounds*, Benzodiazepinones/*blood , Receptors, Cholecystokinin/*antagonists & inhibitors, Benzodiazepinones/pharmacology ; Chromatography, Liquid ; Humans ; Mass Spectrometry ; Radioimmunoassay |
| مستخلص: | L-365,260 is a novel cholecystokinin receptor antagonist. A sensitive and specific liquid chromatographic/mass spectrometric assay has been developed for the determination of the drug in plasma using the CD3-labeled species as the internal standard. Plasma extracts were separated on a 3 cm C18 reverse-phase high-performance liquid chromatography column. The column eluate passed, by means of a heated nebulizer interface, into a corona discharge atmospheric chemical ionization source. The mass spectrometer was operated in the positive ion tandem mass spectrometric mode. The method has sufficient sensitivity, specificity, precision, accuracy and selectivity for the determination of drug concentrations in clinical samples. The chromatographic run time is less than 2 min. |
| المشرفين على المادة: | 0 (Benzodiazepinones) 0 (Phenylurea Compounds) 0 (Receptors, Cholecystokinin) 370JHF4586 (L 365260) |
| تواريخ الأحداث: | Date Created: 19920201 Date Completed: 19920723 Latest Revision: 20161123 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1002/bms.1200210202 |
| PMID: | 1606183 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1052-9306 |
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| DOI: | 10.1002/bms.1200210202 |