دورية أكاديمية
Control of eosinophil toxicity in the lung.
| العنوان: | Control of eosinophil toxicity in the lung. |
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| المؤلفون: | Walsh GM; Allergic and Asthmatic Inflammation Group, School of Medicine, University of Aberdeen, Scotland, UK. g.m.walsh@abdn.ac.uk, Al-Rabia M, Blaylock MG, Sexton DW, Duncan CJ, Lawrie A |
| المصدر: | Current drug targets. Inflammation and allergy [Curr Drug Targets Inflamm Allergy] 2005 Aug; Vol. 4 (4), pp. 481-6. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: Netherlands NLM ID: 101160019 Publication Model: Print Cited Medium: Print ISSN: 1568-010X (Print) Linking ISSN: 1568010X NLM ISO Abbreviation: Curr Drug Targets Inflamm Allergy Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <-2005>: Saif Zone, Sharjah, U.A.E.; San Francisco, CA : Bentham Science Publishers Original Publication: Hilversum, Netherlands ; San Francisco, CA : Bentham Science Publishers, c2002-c2005. |
| مواضيع طبية MeSH: | Eosinophils/*physiology , Lung/*physiology, Animals ; Anti-Asthmatic Agents/pharmacology ; Anti-Asthmatic Agents/therapeutic use ; Apoptosis/physiology ; Asthma/drug therapy ; Asthma/pathology ; Cell Adhesion Molecules/metabolism ; Chemokine CCL11 ; Chemokines, CC/physiology ; Eosinophils/pathology ; Humans ; Lung/pathology ; Phagocytosis/physiology |
| مستخلص: | The inappropriate accumulation of eosinophils and the subsequent release of their potent pro-inflammatory mediator arsenal are thought to be important contributors to the pathogenesis of asthma and other allergic diseases. It is also becoming apparent that eosinophils may play a role in the orchestration of immune responses in the asthmatic lung. There is therefore much interest in the development of strategies to limit or prevent eosinophil-induced toxicity. The mechanisms by which eosinophils accumulate in the peribronchial tissues of the lung are complex and include enhanced differentiation and release from the bone marrow, selective adhesion and transendothelial migration, directed movement in response to specific chemotactic mediators and finally prolonged survival as a consequence of delayed apoptosis. Thus it can be appreciated that there are many points at which the toxicity of eosinophils can be limited or even prevented. Important areas for potential advances in glucocorticoid (GC) development include efforts to dissociate their anti-inflammatory effects from unwanted side effects. Other areas include the development of humanized monoclonal antibodies against IL-4, IL-13 and IL-5 together with the inhibition of adhesion pathways and/or chemokines responsible for eosinophil accumulation in the asthmatic lung. Several avenues of research are currently underway in an attempt to define mechanisms by which pro-inflammatory cells such as eosinophils can be safely removed from the asthmatic lung through apoptosis induction and their subsequent ingestion by phagocytes. This review will discuss both the potential and shortcomings of these diverse approaches to limit eosinophil toxicity in the asthmatic lung. |
| Number of References: | 125 |
| المشرفين على المادة: | 0 (Anti-Asthmatic Agents) 0 (CCL11 protein, human) 0 (Cell Adhesion Molecules) 0 (Chemokine CCL11) 0 (Chemokines, CC) |
| تواريخ الأحداث: | Date Created: 20050817 Date Completed: 20050927 Latest Revision: 20191109 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2174/1568010054526296 |
| PMID: | 16101525 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1568-010X |
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| DOI: | 10.2174/1568010054526296 |