دورية أكاديمية
أعرض في EDS

G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.

التفاصيل البيبلوغرافية
العنوان: G1 checkpoint failure and increased tumor susceptibility in mice lacking the novel p53 target Ptprv.
المؤلفون: Doumont G; Laboratory for Molecular Cancer Biology, Flanders Interuniversity Institute for Biotechnology (VIB), University of Ghent, Ghent, Belgium., Martoriati A, Beekman C, Bogaerts S, Mee PJ, Bureau F, Colombo E, Alcalay M, Bellefroid E, Marchesi F, Scanziani E, Pelicci PG, Marine JC
المصدر: The EMBO journal [EMBO J] 2005 Sep 07; Vol. 24 (17), pp. 3093-103. Date of Electronic Publication: 2005 Aug 18.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0261-4189 (Print) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : [London] : Nature Publishing Group
Original Publication: Eynsham, Oxford, England : Published for the European Molecular Biology Organization by IRL Press, [c1982-
مواضيع طبية MeSH: G1 Phase/*physiology , Papilloma/*metabolism , Protein Tyrosine Phosphatases/*metabolism , Skin Neoplasms/*metabolism , Tumor Suppressor Protein p53/*physiology, 9,10-Dimethyl-1,2-benzanthracene ; Amino Acid Sequence ; Animals ; Apoptosis ; Carcinogens ; Cells, Cultured ; DNA Damage ; Embryo, Mammalian/metabolism ; Epithelial Cells/metabolism ; Fibroblasts/metabolism ; Intestinal Mucosa/cytology ; Intestinal Mucosa/metabolism ; Intestine, Small/metabolism ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Mutation ; Papilloma/chemically induced ; Promoter Regions, Genetic ; Protein Tyrosine Phosphatases/genetics ; Proto-Oncogene Proteins/genetics ; Receptor-Like Protein Tyrosine Phosphatases, Class 3 ; Skin Neoplasms/chemically induced ; Transcription, Genetic ; Ubiquitin-Protein Ligases/genetics
مستخلص: In response to DNA damage, p53 activates a G1 cell cycle checkpoint, in part through induction of the cyclin-dependent kinase inhibitor p21(Waf1/Cip1). Here we report the identification of a new direct p53 target, Ptprv (or ESP), encoding a transmembrane tyrosine phosphatase. Ptprv transcription is dramatically and preferentially increased in cultured cells undergoing p53-dependent cell cycle arrest, but not in cells undergoing p53-mediated apoptosis. This observation was further confirmed in vivo using a Ptprv null-reporter mouse line. A p53-responsive element is present in the Ptprv promoter and p53 is recruited to this site in vivo. Importantly, while p53-dependent apoptosis is intact in mice lacking Ptprv, Ptprv-null fibroblasts and epithelial cells of the small intestine are defective in G1 checkpoint control. Thus, Ptprv is a new direct p53 target and a key mediator of p53-induced cell cycle arrest. Finally, Ptprv loss enhances the formation of epidermal papillomas after exposure to chemical carcinogens, suggesting that Ptprv acts to suppress tumor formation in vivo.
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المشرفين على المادة: 0 (Carcinogens)
0 (Mdm4 protein, mouse)
0 (Proto-Oncogene Proteins)
0 (Tumor Suppressor Protein p53)
57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
EC 2.3.2.27 (Ubiquitin-Protein Ligases)
EC 3.1.3.48 (Protein Tyrosine Phosphatases)
EC 3.1.3.48 (Ptprv protein, mouse)
EC 3.1.3.48 (Receptor-Like Protein Tyrosine Phosphatases, Class 3)
تواريخ الأحداث: Date Created: 20050819 Date Completed: 20051025 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC1201350
DOI: 10.1038/sj.emboj.7600769
PMID: 16107883
قاعدة البيانات: MEDLINE
الوصف
تدمد:0261-4189
DOI:10.1038/sj.emboj.7600769