دورية أكاديمية
Ent-kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosa.
| العنوان: | Ent-kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosa. |
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| المؤلفون: | Kos O; Institute of Pharmaceutical Sciences, Department of Pharmaceutical Biology and Biotechnology, Albert-Ludwigs-University of Freiburg, Stefan-Meier-Street 19, 79104 Freiburg, Germany., Castro V, Murillo R, Poveda L, Merfort I |
| المصدر: | Phytochemistry [Phytochemistry] 2006 Jan; Vol. 67 (1), pp. 62-9. Date of Electronic Publication: 2005 Aug 29. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: England NLM ID: 0151434 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0031-9422 (Print) Linking ISSN: 00319422 NLM ISO Abbreviation: Phytochemistry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : London : Elsevier Original Publication: 1961-2003: Oxford : Pergamon Press. |
| مواضيع طبية MeSH: | Disaccharides/*chemistry , Diterpenes, Kaurane/*chemistry , Glycosides/*chemistry , Lactones/*chemistry , Sesquiterpenes/*chemistry , Vernonia/*chemistry, Cells, Cultured ; Crystallography, X-Ray ; DNA/drug effects ; DNA/metabolism ; Disaccharides/isolation & purification ; Diterpenes, Kaurane/isolation & purification ; Diterpenes, Kaurane/pharmacology ; Glycosides/isolation & purification ; Glycosides/pharmacology ; HeLa Cells ; Humans ; Interleukin-8/antagonists & inhibitors ; Lactones/isolation & purification ; Lactones/pharmacology ; Magnetic Resonance Spectroscopy/methods ; Magnetic Resonance Spectroscopy/standards ; Models, Molecular ; Molecular Conformation ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/metabolism ; Reference Standards ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/pharmacology ; Species Specificity ; Stereoisomerism |
| مستخلص: | Investigation of the aerial parts of Vernonia triflosculosa afforded three hirsutinolides of which 8alpha-(4alpha-hydroxymethacryloyloxy)-10alpha-hydroxy-1,13-dimethoxy-hirsutinolide is new, three ent-kaurane diterpenes, among which the 19-[alpha-L-arabinopyranosyl-(1-->2)-beta-D-glucopyranosyl] esters of 16beta-hydroxy-ent-kauran-19-oic acid and of 16beta,17-hydroxy-ent-kauran-19-oic acid are also new. Diterpenes are reported here for the first time in the large genus Vernonia. Their structures were elucidated using 1D and 2D NMR measurement as well as ESI, CIMS, and HRMS analysis. Two hirsutinolides were studied for their NF-kappaB DNA binding activity in HaCaT cells (a human cell line similar to keratinocytes) and for their inhibition on IL-8 production in HeLa cells. |
| المشرفين على المادة: | 0 (16,17-dihydroxy-ent-kauran-19-oic acid-19-(arabinopyranosyl-1-2-glucopyranosyl) ester) 0 (16-hydroxy-ent-kauran-19-oic acid-19-(arabinopyranosyl-1-2-glucopyranosyl) ester) 0 (8-(4-hydroxymethacryloyloxy)-10-hydroxy-1,13-dimethoxyhirsutinolide) 0 (Disaccharides) 0 (Diterpenes, Kaurane) 0 (Glycosides) 0 (Interleukin-8) 0 (Lactones) 0 (NF-kappa B) 0 (Sesquiterpenes) 9007-49-2 (DNA) |
| تواريخ الأحداث: | Date Created: 20050901 Date Completed: 20060417 Latest Revision: 20061115 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.phytochem.2005.07.006 |
| PMID: | 16129464 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0031-9422 |
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| DOI: | 10.1016/j.phytochem.2005.07.006 |