دورية أكاديمية
Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia.
| العنوان: | Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia. |
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| المؤلفون: | Comella CL; Rush University Medical Center, Chicago, IL 60612, USA. ccomella@rush.edu, Jankovic J, Shannon KM, Tsui J, Swenson M, Leurgans S, Fan W |
| مؤلفون مشاركون: | Dystonia Study Group |
| المصدر: | Neurology [Neurology] 2005 Nov 08; Vol. 65 (9), pp. 1423-9. |
| نوع المنشور: | Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Minneapolis. |
| مواضيع طبية MeSH: | Botulinum Toxins/*administration & dosage , Botulinum Toxins, Type A/*administration & dosage , Neck Muscles/*drug effects , Torticollis/*drug therapy, Adult ; Aged ; Botulinum Toxins/adverse effects ; Botulinum Toxins, Type A/adverse effects ; Deglutition Disorders/chemically induced ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Muscle Weakness/chemically induced ; Muscle Weakness/physiopathology ; Neck Muscles/innervation ; Neck Muscles/physiopathology ; Time ; Time Factors ; Torticollis/physiopathology ; Treatment Outcome ; Xerostomia/chemically induced |
| مستخلص: | Objective: To directly compare two serotypes of botulinum toxin (BoNTA and BoNTB) in cervical dystonia (CD) using a randomized, double-blind, parallel-arm study design. Methods: Subjects with CD who had a previous response from BoNTA were randomly assigned to BoNTA or BoNTB and evaluated in a blinded fashion at baseline, 4 weeks, 8 weeks, and 2-week intervals thereafter until loss of 80% of clinical effect or completion of 20 weeks of observation. CD severity was measured with the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), and adverse events were assessed by structured interview. Statistical analysis included Wilcoxon rank sum test, log rank tests, and Kaplan-Meier survival curves for duration of effect. Results: A total of 139 subjects (BoNTA, n = 74; BoNTB, n = 65) were randomized at 19 study sites. Improvement in TWSTRS score was found at 4 weeks after injection and did not differ between serotypes. Dysphagia and dry mouth were more frequent with BoNTB (dysphagia: BoNTA 19% vs BoNTB 48%, p = 0.0005; dry mouth (BoNTA 41% vs BoNTB 80%, p < 0.0001). In clinical responders, BoNT A had a modestly longer duration of benefit (BoNTA 14 weeks, BoNTB 12.1 weeks, p = 0.033). Conclusion: Both serotypes of botulinum toxin (BoNTA and BoNTB) had equivalent benefit in subjects with cervical dystonia at 4 weeks. BoNTA had fewer adverse events and a marginally longer duration of effect in subjects showing a clinical response. |
| المشرفين على المادة: | 0Y70779M1F (rimabotulinumtoxinB) EC 3.4.24.69 (Botulinum Toxins) EC 3.4.24.69 (Botulinum Toxins, Type A) |
| تواريخ الأحداث: | Date Created: 20051109 Date Completed: 20060412 Latest Revision: 20131125 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1212/01.wnl.0000183055.81056.5c |
| PMID: | 16275831 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1526-632X |
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| DOI: | 10.1212/01.wnl.0000183055.81056.5c |