التفاصيل البيبلوغرافية
| العنوان: |
HIV-infected cells are major inducers of plasmacytoid dendritic cell interferon production, maturation, and migration. |
| المؤلفون: |
Schmidt B; Department of Medicine, Division Hematology/Oncology, University of California, San Francisco, CA 94143-0128, USA., Ashlock BM, Foster H, Fujimura SH, Levy JA |
| المصدر: |
Virology [Virology] 2005 Dec 20; Vol. 343 (2), pp. 256-66. Date of Electronic Publication: 2005 Nov 08. |
| نوع المنشور: |
Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0042-6822 (Print) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: |
Dendritic Cells/*immunology , HIV Infections/*immunology , Interferon Type I/*biosynthesis, CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/virology ; Cell Communication/immunology ; Cell Differentiation ; Cell Movement ; Coculture Techniques ; Dendritic Cells/pathology ; Dendritic Cells/physiology ; Endocytosis ; HIV Infections/pathology ; HIV Infections/physiopathology ; HIV-1/immunology ; HIV-1/physiology ; Humans ; Immunity, Innate ; Plasma Cells/immunology ; Plasma Cells/pathology ; Plasma Cells/physiology |
| مستخلص: |
Plasmacytoid dendritic cells (PDC), natural type-1 interferon (IFN) producing cells, could play a role in the innate anti-HIV immune response. Previous reports indicated that PDC IFN production is induced by HIV. Our results show a more robust IFN induction when purified PDC (>95%) were exposed to HIV-infected cells. This effect was not observed with non-viable cells, DNA, and RNA extracted from infected cells, and viral proteins. The response was blocked by anti-CD4 and neutralizing anti-gp120 antibodies as well as soluble CD4. IFN induction by HIV-infected cells was also prevented by low-dose chloroquine, which inhibits endosomal acidification. PDC IFN release resulted in reduced HIV production by infected CD4+ cells, supporting an anti-HIV activity of PDC. Stimulated CD4+ cells induced PDC activation and maturation; markers for PDC migration (CCR7) were enhanced by HIV-infected CD4+ cells only. This latter finding could explain the decline in circulating PDC in HIV-infected individuals. |
| المشرفين على المادة: |
0 (Interferon Type I) |
| تواريخ الأحداث: |
Date Created: 20051110 Date Completed: 20060125 Latest Revision: 20141120 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1016/j.virol.2005.09.059 |
| PMID: |
16278001 |
| قاعدة البيانات: |
MEDLINE |
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