دورية أكاديمية
Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation.
| العنوان: | Bovine bone activin enhances bone morphogenetic protein-induced ectopic bone formation. |
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| المؤلفون: | Ogawa Y; Celtrix Pharmaceuticals, Palo Alto, California 94303., Schmidt DK, Nathan RM, Armstrong RM, Miller KL, Sawamura SJ, Ziman JM, Erickson KL, de Leon ER, Rosen DM, et. al. |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 1992 Jul 15; Vol. 267 (20), pp. 14233-7. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Bone Development/*drug effects , Bone and Bones/*physiology , Growth Substances/*pharmacology , Hematopoiesis/*drug effects , Inhibins/*pharmacology , Pituitary Gland/*metabolism , Proteins/*pharmacology, Activins ; Amino Acid Sequence ; Animals ; Bone Morphogenetic Proteins ; Bone and Bones/drug effects ; Cattle ; Cells, Cultured ; Chromatography, Gel ; Cyanogen Bromide ; Follicle Stimulating Hormone/metabolism ; In Vitro Techniques ; Inhibins/isolation & purification ; Male ; Mice ; Mice, Inbred C57BL ; Molecular Sequence Data ; Peptide Fragments/isolation & purification ; Pituitary Gland/drug effects ; Proteins/isolation & purification ; Rats ; Rats, Inbred Strains ; Transforming Growth Factor beta/isolation & purification ; Transforming Growth Factor beta/pharmacology |
| مستخلص: | A 25-kDa homodimeric protein was purified from demineralized bovine bone extract and identified as activin A. The bovine bone activin enhanced formation of ectopic bone in rat subcutis when implanted in combination with partially purified bovine bone morphogenetic protein (BMP-2, BMP-3) in collagen/ceramic carrier. The implants, removed at 14 days, contained markedly elevated levels of alkaline phosphatase activity. Histological examination revealed an extensive formation of woven bone with very little cartilage. In contrast, a combination of transforming growth factor-beta 2 and BMP promoted formation of bone with an abundance of cartilage. The implants with BMP alone exhibited some osteoinductive activity, while the implants with activin alone showed no activity. These results demonstrate that bone is a rich source of activin and that activin plays an important role in modulating bone formation. |
| المشرفين على المادة: | 0 (Bone Morphogenetic Proteins) 0 (Growth Substances) 0 (Peptide Fragments) 0 (Proteins) 0 (Transforming Growth Factor beta) 104625-48-1 (Activins) 57285-09-3 (Inhibins) 9002-68-0 (Follicle Stimulating Hormone) OS382OHJ8P (Cyanogen Bromide) |
| تواريخ الأحداث: | Date Created: 19920715 Date Completed: 19920814 Latest Revision: 20210210 |
| رمز التحديث: | 20240627 |
| PMID: | 1629219 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0021-9258 |
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