دورية أكاديمية
Effect of amlodipine on 24-hour ambulatory blood pressure in hypertensive patients.
| العنوان: | Effect of amlodipine on 24-hour ambulatory blood pressure in hypertensive patients. |
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| المؤلفون: | Mroczek WJ; Cardiovascular Center of Northern Virginia, 6045 Arlington Boulevard, Falls Church, VA 22044, USA., Burris JF, Allenby KS |
| المصدر: | Journal of cardiovascular pharmacology [J Cardiovasc Pharmacol] 1991; Vol. 17 Suppl 1, pp. S13-5. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7902492 Publication Model: Print Cited Medium: Print ISSN: 0160-2446 (Print) Linking ISSN: 01602446 NLM ISO Abbreviation: J Cardiovasc Pharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: New York, Raven Press. |
| مواضيع طبية MeSH: | Amlodipine/*therapeutic use , Blood Pressure/*drug effects , Calcium Channel Blockers/*therapeutic use , Hypertension/*drug therapy, Aged ; Amlodipine/administration & dosage ; Amlodipine/adverse effects ; Blood Pressure Monitoring, Ambulatory ; Calcium Channel Blockers/administration & dosage ; Calcium Channel Blockers/adverse effects ; Double-Blind Method ; Drug Administration Schedule ; Female ; Humans ; Hypertension/physiopathology ; Male ; Middle Aged |
| مستخلص: | Sixteen hypertensive patients (diastolic blood pressure of 95-114 mm Hg) were randomized to receive 5 mg of amlodipine daily or placebo, double blind, for 4 weeks. Antihypertensive efficacy was assessed using ambulatory blood pressure monitoring at baseline and following double-blind therapy in conjunction with sphygmomanometric measurement at 2-week intervals. Laboratory tests, ECG, and adverse effects were recorded to assess tolerability. Amlodipine treatment significantly reduced ambulatory blood pressure without altering the normal circadian variation throughout the monitoring period. Supine and standing blood pressure were significantly reduced by amlodipine 24 h postdose. Amlodipine was well tolerated and was not associated with reflex tachycardia. |
| المشرفين على المادة: | 0 (Calcium Channel Blockers) 1J444QC288 (Amlodipine) |
| تواريخ الأحداث: | Date Created: 19910101 Date Completed: 20051213 Latest Revision: 20190724 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1097/00005344-199117001-00005 |
| PMID: | 16296699 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0160-2446 |
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| DOI: | 10.1097/00005344-199117001-00005 |