دورية أكاديمية
أعرض في EDS

Responsiveness of the aging circadian clock to light.

التفاصيل البيبلوغرافية
العنوان: Responsiveness of the aging circadian clock to light.
المؤلفون: Benloucif S; Department of Neurology, Abbott Hall, 11th flr, Northwestern University Feinberg School of Medicine, 710 N. Lake Shore Drive, Chicago, IL 60611, USA. sbenloucif@aasmnet.org , Green K, L'Hermite-Balériaux M, Weintraub S, Wolfe LF, Zee PC
المصدر: Neurobiology of aging [Neurobiol Aging] 2006 Dec; Vol. 27 (12), pp. 1870-9. Date of Electronic Publication: 2005 Nov 23.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 8100437 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-1497 (Electronic) Linking ISSN: 01974580 NLM ISO Abbreviation: Neurobiol Aging Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Elsevier
Original Publication: Fayetteville, N.Y. : Ankho International.
مواضيع طبية MeSH: Adaptation, Physiological/*physiology , Aging/*physiology , Circadian Rhythm/*physiology , Photic Stimulation/*methods, Adult ; Aged ; Female ; Humans ; Male ; Melatonin/blood ; Middle Aged ; Sleep Stages/physiology
مستخلص: The present study assessed whether advances in sleep times and circadian phase in older adults might be due to decreased responsiveness of the aging circadian clock to light. Sixteen young (29.3+/-5.6 years) and 14 older adults (67.1+/-7.4 years) were exposed to 4h of control dim (10lux) or bright light (3500lux) during the night. Phase shifts of the melatonin rhythm were assessed from the nights before and after the light exposure. Bright light delayed the melatonin midpoint in both young and older adults (p<0.001). Phase delays for the older subjects were not significantly different from those of the young subjects for either the bright or dim light conditions. The magnitude of phase delays was correlated with both sleep offset and phase angle in the older, but not the younger subjects. The present results indicate that at light intensities commonly used in research as well as clinical practice older adults are able to phase delay to the same extent as younger subjects.
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معلومات مُعتمدة: P30 AG013854 United States AG NIA NIH HHS; P01 AG11412 United States AG NIA NIH HHS; R01 HL067604 United States HL NHLBI NIH HHS; AG13854 United States AG NIA NIH HHS; R01 HL67604 United States HL NHLBI NIH HHS; K01 AG00810 United States AG NIA NIH HHS; P01 AG011412 United States AG NIA NIH HHS
المشرفين على المادة: JL5DK93RCL (Melatonin)
تواريخ الأحداث: Date Created: 20051129 Date Completed: 20070103 Latest Revision: 20181113
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC1866218
DOI: 10.1016/j.neurobiolaging.2005.10.011
PMID: 16309797
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-1497
DOI:10.1016/j.neurobiolaging.2005.10.011