دورية أكاديمية
Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning.
| العنوان: | Global gene expression profiles reveal significant nuclear reprogramming by the blastocyst stage after cloning. |
|---|---|
| المؤلفون: | Smith SL; Center for Regenerative Biology/Department of Animal Science, University of Connecticut, Storrs, CT 06269, USA., Everts RE, Tian XC, Du F, Sung LY, Rodriguez-Zas SL, Jeong BS, Renard JP, Lewin HA, Yang X |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2005 Dec 06; Vol. 102 (49), pp. 17582-7. Date of Electronic Publication: 2005 Nov 28. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Cloning, Organism* , Gene Expression Profiling*, Blastocyst/*cytology , Blastocyst/*metabolism , Cell Nucleus/*genetics , Cell Nucleus/*physiology, Animals ; Cattle ; Fertilization in Vitro ; Insemination, Artificial ; Oligonucleotide Array Sequence Analysis ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Up-Regulation/genetics |
| مستخلص: | Nuclear transfer (NT) has potential applications in agriculture and biomedicine, but the technology is hindered by low efficiency. Global gene expression analysis of clones is important for the comprehensive study of nuclear reprogramming. Here, we compared global gene expression profiles of individual bovine NT blastocysts with their somatic donor cells and fertilized control embryos using cDNA microarray technology. The NT embryos' gene expression profiles were drastically different from those of their donor cells and closely resembled those of the naturally fertilized embryos. Our findings demonstrate that the NT embryos have undergone significant nuclear reprogramming by the blastocyst stage; however, problems may occur during redifferentiation for tissue genesis and organogenesis, and small reprogramming errors may be magnified downstream in development. |
| References: | Biol Reprod. 2005 Mar;72(3):546-55. (PMID: 15483223) Mech Dev. 2000 Apr;92(2):295-9. (PMID: 10727869) Vet Immunol Immunopathol. 2005 May 15;105(3-4):235-45. (PMID: 15808303) Nat Biotechnol. 2005 Jun;23(6):699-708. (PMID: 15940242) Science. 2005 Jun 17;308(5729):1777-83. (PMID: 15905366) Biol Reprod. 2005 Jul;73(1):149-55. (PMID: 15744021) Cell. 1999 Oct 29;99(3):247-57. (PMID: 10555141) Nat Biotechnol. 2000 Apr;18(4):457-9. (PMID: 10748532) Mol Reprod Dev. 2000 Jun;56(2):113-23. (PMID: 10813842) Biol Reprod. 2000 Oct;63(4):1034-40. (PMID: 10993824) Biotechniques. 2000 Sep;29(3):548-50, 552-4, 556 passim. (PMID: 10997270) Nucleic Acids Res. 2001 Jan 1;29(1):275-6. (PMID: 11125110) Nucleic Acids Res. 2001 Mar 1;29(5):E29. (PMID: 11222780) Nat Genet. 2001 Jun;28(2):173-7. (PMID: 11381267) Biol Reprod. 2001 Jul;65(1):309-17. (PMID: 11420254) Curr Biol. 2001 Oct 2;11(19):1542-6. (PMID: 11591324) Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13734-8. (PMID: 11717434) Mech Dev. 2002 Jan;110(1-2):139-49. (PMID: 11744375) J Comput Biol. 2001;8(6):625-37. (PMID: 11747616) Biol Reprod. 2002 Jan;66(1):127-34. (PMID: 11751274) Am J Pathol. 2002 Mar;160(3):801-13. (PMID: 11891179) Nat Genet. 2002 Jun;31(2):216-20. (PMID: 12032569) Nat Rev Genet. 2002 Sep;3(9):662-73. (PMID: 12209141) Anim Biotechnol. 2002 May;13(1):163-72. (PMID: 12212940) Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12889-94. (PMID: 12235366) Science. 2002 Oct 18;298(5593):597-600. (PMID: 12228720) Science. 2002 Oct 18;298(5593):601-4. (PMID: 12228721) Genome Biol. 2003;4(5):P3. (PMID: 12734009) Nat Cell Biol. 2003 Jun;5(6):513-9. (PMID: 12766772) Curr Biol. 2003 Jul 1;13(13):1116-21. (PMID: 12842010) Dev Biol. 2003 Aug 15;260(2):404-13. (PMID: 12921741) Biol Reprod. 2003 Sep;69(3):902-14. (PMID: 12748125) Genome Biol. 2003;4(10):R70. (PMID: 14519205) Reproduction. 2003 Oct;126(4):549-57. (PMID: 14525537) Zygote. 2003 Aug;11(3):245-52. (PMID: 14640189) Mol Pathol. 2003 Dec;56(6):307-12. (PMID: 14645691) Hum Mol Genet. 2004 Mar 15;13(6):601-8. (PMID: 14749348) Dev Biol. 2004 Mar 15;267(2):399-417. (PMID: 15013802) Development. 2004 Apr;131(7):1619-28. (PMID: 14998921) Nature. 2004 Mar 25;428(6981):393-9. (PMID: 15042081) Bioessays. 2004 Jul;26(7):766-77. (PMID: 15221858) Biol Reprod. 2004 Nov;71(5):1671-6. (PMID: 15253921) Nature. 1997 Feb 27;385(6619):810-3. (PMID: 9039911) Biol Reprod. 1997 May;56(5):1323-9. (PMID: 9160734) Mol Reprod Dev. 1998 Nov;51(3):281-6. (PMID: 9771648) Science. 1998 Nov 6;282(5391):1145-7. (PMID: 9804556) Biol Reprod. 1999 Mar;60(3):769-75. (PMID: 10026129) Nat Genet. 1999 Oct;23(2):228-32. (PMID: 10508523) Nat Genet. 2004 Dec;36(12):1291-5. (PMID: 15516931) Nature. 1999 Nov 25;402(6760):425-9. (PMID: 10586884) Proc Natl Acad Sci U S A. 2000 Feb 1;97(3):990-5. (PMID: 10655472) Theriogenology. 1999 Jun;51(8):1451-65. (PMID: 10729073) Biol Reprod. 2005 Apr;72(4):932-6. (PMID: 15601921) |
| المشرفين على المادة: | 0 (RNA, Messenger) |
| تواريخ الأحداث: | Date Created: 20051130 Date Completed: 20060118 Latest Revision: 20181113 |
| رمز التحديث: | 20240513 |
| مُعرف محوري في PubMed: | PMC1308920 |
| DOI: | 10.1073/pnas.0508952102 |
| PMID: | 16314565 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0027-8424 |
|---|---|
| DOI: | 10.1073/pnas.0508952102 |