دورية أكاديمية
CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics.
| العنوان: | CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics. |
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| المؤلفون: | Sloan KE; Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA., Stewart JK, Treloar AF, Matthews RT, Jay DG |
| المصدر: | Cancer research [Cancer Res] 2005 Dec 01; Vol. 65 (23), pp. 10930-7. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Baltimore, Md. : American Association for Cancer Research Original Publication: Chicago [etc.] |
| مواضيع طبية MeSH: | Brain Neoplasms/*pathology , Cell Movement/*physiology , Glioma/*pathology , Membrane Proteins/*physiology , Receptors, Virus/*physiology, Animals ; Brain Neoplasms/genetics ; Brain Neoplasms/metabolism ; Cell Adhesion/physiology ; Cell Line, Tumor ; Focal Adhesions/physiology ; Glioma/genetics ; Glioma/metabolism ; Humans ; Membrane Proteins/biosynthesis ; Membrane Proteins/deficiency ; Membrane Proteins/genetics ; Rats ; Receptors, Virus/biosynthesis ; Receptors, Virus/deficiency ; Receptors, Virus/genetics ; Signal Transduction ; Transfection |
| مستخلص: | We recently identified the immunoglobulin-CAM CD155/PVR (the poliovirus receptor) as a regulator of cancer invasiveness and glioma migration, but the mechanism through which CD155/PVR controls these processes is unknown. Here, we show that expression of CD155/PVR in rat glioma cells that normally lack this protein enhances their dispersal both in vitro and on primary brain tissue. CD155/PVR expression also reduced substrate adhesion, cell spreading, focal adhesion density, and the number of actin stress fibers in a substrate-dependent manner. Furthermore, we found that expression of CD155/PVR increased Src/focal adhesion kinase signaling in a substrate-dependent manner, enhancing the adhesion-induced activation of paxillin and p130Cas in cells adhering to vitronectin. Conversely, depletion of endogenous CD155/PVR from human glioma cells inhibited their migration, increased cell spreading, and down-regulated the same signaling pathway. These findings implicate CD155/PVR as a regulator of adhesion signaling and suggest a pathway through which glioma and other cancer cells may acquire a dispersive phenotype. |
| معلومات مُعتمدة: | CA-81668 United States CA NCI NIH HHS; DK-07542 United States DK NIDDK NIH HHS |
| المشرفين على المادة: | 0 (Membrane Proteins) 0 (Receptors, Virus) 0 (poliovirus receptor) |
| تواريخ الأحداث: | Date Created: 20051203 Date Completed: 20060125 Latest Revision: 20231120 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1158/0008-5472.CAN-05-1890 |
| PMID: | 16322240 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0008-5472 |
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| DOI: | 10.1158/0008-5472.CAN-05-1890 |