دورية أكاديمية
Bronchogenic carcinoma in solid organ transplant recipients.
| العنوان: | Bronchogenic carcinoma in solid organ transplant recipients. |
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| المؤلفون: | Bellil Y; University of Maryland Greenebaum Cancer Center, Baltimore, MD 21201, USA., Edelman MJ |
| المصدر: | Current treatment options in oncology [Curr Treat Options Oncol] 2006 Jan; Vol. 7 (1), pp. 77-81. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Current Science, Inc Country of Publication: United States NLM ID: 100900946 Publication Model: Print Cited Medium: Print ISSN: 1527-2729 (Print) Linking ISSN: 15346277 NLM ISO Abbreviation: Curr Treat Options Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : Current Science, Inc., |
| مواضيع طبية MeSH: | Heart Transplantation/*adverse effects , Liver Transplantation/*adverse effects , Lung Neoplasms/*etiology , Lung Transplantation/*adverse effects, Humans ; Immunosuppressive Agents/adverse effects ; Immunosuppressive Agents/therapeutic use ; Lung Neoplasms/prevention & control ; Risk Factors |
| مستخلص: | Malignancies are increased in some types of solid organ transplant patients receiving immunosuppressive therapy and are a significant contributor to patient morbidity and mortality. There may be a 100-fold increase in the incidence of de novo neoplasia in this population. The risk of lymphoproliferative malignancies is well appreciated. In contrast, the risk of solid tumors with their consequent morbidity and mortality is less well known, probably because of their common occurrence in the general population. Lung cancer is the most common cause of cancer death in the United States; therefore, lung cancer in patients undergoing organ transplantation would be expected to occur frequently on the basis of chance alone. However, the lung cancer risk is approximately 20 to 25 times that of the general population, with an incidence of 0.28% to 4.1% in patients after heart and lung transplant. Risk factors thought to contribute include cigarette smoking, advanced age at transplantation, and chronic immunosuppressive therapy. The role of transplantation (and consequent therapy) in the development of lung cancer in this high-risk population remains unclear. As in the nontransplant population, adequate screening techniques are lacking, making early diagnosis and treatment a challenge. Despite close follow-up and routine imaging with chest radiography and CT, lung cancers continue to be discovered incidentally and at advanced stages. Treatment is similar to that of patients who are nontransplanted with similar stage, histology, and performance status. |
| Number of References: | 45 |
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| المشرفين على المادة: | 0 (Immunosuppressive Agents) |
| تواريخ الأحداث: | Date Created: 20051214 Date Completed: 20060321 Latest Revision: 20220716 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s11864-006-0034-5 |
| PMID: | 16343371 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1527-2729 |
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| DOI: | 10.1007/s11864-006-0034-5 |