دورية أكاديمية
أعرض في EDS

Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection.

التفاصيل البيبلوغرافية
العنوان: Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection.
المؤلفون: Chan VS; Department of Surgery, Hong Kong Jockey Club Clinical Research Center, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, SAR, China., Chan KY, Chen Y, Poon LL, Cheung AN, Zheng B, Chan KH, Mak W, Ngan HY, Xu X, Screaton G, Tam PK, Austyn JM, Chan LC, Yip SP, Peiris M, Khoo US, Lin CL
المصدر: Nature genetics [Nat Genet] 2006 Jan; Vol. 38 (1), pp. 38-46. Date of Electronic Publication: 2005 Dec 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1061-4036 (Print) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Nature Pub. Co., c1992-
مواضيع طبية MeSH: Cell Adhesion Molecules/*genetics , Lectins, C-Type/*genetics , Receptors, Cell Surface/*genetics , Severe acute respiratory syndrome-related coronavirus/*pathogenicity , Severe Acute Respiratory Syndrome/*genetics, Animals ; CHO Cells/virology ; Cell Adhesion Molecules/metabolism ; Chlorocebus aethiops ; Cohort Studies ; Cricetinae ; Cricetulus ; Genetic Predisposition to Disease ; Homozygote ; Hong Kong/epidemiology ; Humans ; Intestine, Small/physiology ; Lectins, C-Type/metabolism ; Lung/physiology ; Lung/virology ; Molecular Sequence Data ; Proteasome Endopeptidase Complex/metabolism ; Receptors, Cell Surface/metabolism ; Severe acute respiratory syndrome-related coronavirus/metabolism ; Severe Acute Respiratory Syndrome/epidemiology ; Tandem Repeat Sequences ; Vero Cells/virology
مستخلص: Severe acute respiratory syndrome (SARS) is caused by infection of a previously undescribed coronavirus (CoV). L-SIGN, encoded by CLEC4M (also known as CD209L), is a SARS-CoV binding receptor that has polymorphism in its extracellular neck region encoded by the tandem repeat domain in exon 4. Our genetic risk association study shows that individuals homozygous for CLEC4M tandem repeats are less susceptible to SARS infection. L-SIGN is expressed in both non-SARS and SARS-CoV-infected lung. Compared with cells heterozygous for L-SIGN, cells homozygous for L-SIGN show higher binding capacity for SARS-CoV, higher proteasome-dependent viral degradation and a lower capacity for trans infection. Thus, homozygosity for L-SIGN plays a protective role during SARS infection.
التعليقات: Comment in: Nat Genet. 2007 Jun;39(6):691-2; author reply 694-6. (PMID: 17534354)
Comment in: Nat Genet. 2007 Jun;39(6):692-4; author reply 694-6. (PMID: 17534355)
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سلسلة جزيئية: GENBANK AB046569; AF290887
المشرفين على المادة: 0 (CLEC4M protein, human)
0 (Cell Adhesion Molecules)
0 (Lectins, C-Type)
0 (Receptors, Cell Surface)
EC 3.4.25.1 (Proteasome Endopeptidase Complex)
تواريخ الأحداث: Date Created: 20051222 Date Completed: 20060307 Latest Revision: 20240417
رمز التحديث: 20240417
مُعرف محوري في PubMed: PMC7097088
DOI: 10.1038/ng1698
PMID: 16369534
قاعدة البيانات: MEDLINE
الوصف
تدمد:1061-4036
DOI:10.1038/ng1698