دورية أكاديمية
Graft failure following reduced-intensity cord blood transplantation for adult patients.
| العنوان: | Graft failure following reduced-intensity cord blood transplantation for adult patients. |
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| المؤلفون: | Narimatsu H; Department of Haematology, Toranomon Hospital, Tokyo, Japan., Kami M, Miyakoshi S, Murashige N, Yuji K, Hamaki T, Masuoka K, Kusumi E, Kishi Y, Matsumura T, Wake A, Morinaga S, Kanda Y, Taniguchi S |
| المصدر: | British journal of haematology [Br J Haematol] 2006 Jan; Vol. 132 (1), pp. 36-41. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print Cited Medium: Print ISSN: 0007-1048 (Print) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Graft Rejection*, Cord Blood Stem Cell Transplantation/*methods , Hematologic Neoplasms/*therapy, Adolescent ; Adult ; Aged ; Female ; Graft Survival ; Graft vs Host Disease/diagnosis ; Hematologic Neoplasms/complications ; Histocompatibility Testing ; Humans ; Male ; Middle Aged ; Neutropenia/complications ; Opportunistic Infections/complications ; Treatment Outcome |
| مستخلص: | We reviewed the medical records of 123 adult reduced-intensity cord blood transplantation (RI-CBT) recipients to investigate the clinical features of graft failure after RI-CBT. Nine (7.3%) had graft failure, and were classified as graft rejection rather than primary graft failure; they showed peripheral cytopenia with complete loss of donor-type haematopoiesis, implying destruction of donor cells by immunological mechanisms rather than poor graft function. Three of them died of bacterial or fungal infection during neutropenia. Two recovered autologous haematopoiesis. The remaining four patients underwent a second RI-CBT and developed severe regimen-related toxicities. One died of pneumonia on day 8, and the other three achieved engraftment. Two of them died of transplant-related mortality, and the other survived without disease progression for 9.0 months after the second RI-CBT. In total, seven of the nine patients with graft failure died. The median survival of those with graft failure was 3.8 months (range, 0.9-15.4). Graft failure is a serious complication of RI-CBT. As host T cells cannot completely be eliminated by reduced-intensity preparative regimens, we need to be aware of the difficulty in differentiating graft rejection from other causes of graft failure following RI-CBT. Further studies are warranted to establish optimal diagnostic and treatment strategies. |
| تواريخ الأحداث: | Date Created: 20051224 Date Completed: 20060113 Latest Revision: 20051222 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/j.1365-2141.2005.05832.x |
| PMID: | 16371018 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0007-1048 |
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| DOI: | 10.1111/j.1365-2141.2005.05832.x |