دورية أكاديمية
Oxygen carriers: a selected review.
| العنوان: | Oxygen carriers: a selected review. |
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| المؤلفون: | Inayat MS; Department of Clinical Sciences, University of Kentucky, Room 209b, Charles T. Wethington Building, 900 South Limestone Street, Lexington, KY 40536-0200, USA., Bernard AC, Gallicchio VS, Garvy BA, Elford HL, Oakley OR |
| المصدر: | Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2006 Feb; Vol. 34 (1), pp. 25-32. Date of Electronic Publication: 2005 Dec 22. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Country of Publication: England NLM ID: 101095653 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1473-0502 (Print) Linking ISSN: 14730502 NLM ISO Abbreviation: Transfus Apher Sci |
| أسماء مطبوعة: | Original Publication: Oxford : Pergamon : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Blood Substitutes/*chemistry , Blood Transfusion/*methods , Oxygen/*metabolism, Bacterial Infections ; Blood/microbiology ; Blood Banks ; Blood Component Transfusion ; Blood Preservation/methods ; Blood Specimen Collection ; Blood Substitutes/pharmacology ; Drug Design ; Hemoglobins ; Humans ; Models, Chemical |
| مستخلص: | The most common and widely transplanted tissue world wide is blood, which in 2000 resulted in the transfusion of 12.5 million units of blood in the US alone [Goodnough LT, Shander A, Brecher ME. Transfusion medicine: looking to the future. Lancet 2003;361:161-9]. The current use of donated blood products is relatively safe; however, there are inherent problems with allogeneic blood transfusions. The wide spread use of blood in procedures results in problems involving inadequate supply exacerbated in times of war and disasters and by the limited storage life of blood donations (30-42 days). Blood contamination due to patient pre-disposition, poor collection, sterilization, or storage is the second most common cause of death from transfusion in the US [Hillyer CD, Josephson CD, Blajchman MA, Vostal JG, Epstein JS, Goodman JL. Bacterial contamination of blood components: risks, strategies, and regulation: joint ASH and AABB educational session in transfusion medicine. Hematology (Am Soc Hematol Educ Program) 2003:575-89]. Blood is a complex tissue involved in a plethora of homeostatic roles, including immunity, wound healing and the transport of nourishment, electrolytes, hormones, vitamins, heat, oxygen and the removal of metabolic waste products. However, by far the principle role of blood transfusions is the replacement of red cell volume and the maintenance of oxygen levels within the circulation. Creation of investigational new drugs (INDs) which would function as oxygen carriers and prolong shelf life is now a very active arena of scientific research. Several such IND products are now in clinical trials. This article gives an easy to follow concise evaluation of major areas of focus and current testing for each type of blood substitution molecule. |
| Number of References: | 47 |
| معلومات مُعتمدة: | R15 HL084654 United States HL NHLBI NIH HHS; R15 HL084654-01A1 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Blood Substitutes) 0 (Hemoglobins) S88TT14065 (Oxygen) |
| تواريخ الأحداث: | Date Created: 20051227 Date Completed: 20060525 Latest Revision: 20161122 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.transci.2005.09.005 |
| PMID: | 16376617 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-0502 |
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| DOI: | 10.1016/j.transci.2005.09.005 |