دورية أكاديمية
Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods.
| العنوان: | Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods. |
|---|---|
| المؤلفون: | Fonteh AN; Molecular Neurology Program, Huntington Medical Research Institutes, Pasadena, CA 91101, USA. afonteh@hmri.org, Harrington RJ, Huhmer AF, Biringer RG, Riggins JN, Harrington MG |
| المصدر: | Disease markers [Dis Markers] 2006; Vol. 22 (1-2), pp. 39-64. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: Print Cited Medium: Print ISSN: 0278-0240 (Print) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : New York, NY : Hindawi Pub. Corp. Original Publication: Chichester ; New York : Wiley, c1983- |
| مواضيع طبية MeSH: | Cerebrospinal Fluid Proteins/*analysis , Lipids/*cerebrospinal fluid , Mental Disorders/*diagnosis , Nervous System Diseases/*diagnosis , Proteomics/*methods, Biomarkers/cerebrospinal fluid ; Brain/metabolism ; Brain/physiopathology ; Cerebrospinal Fluid Proteins/metabolism ; Humans ; Lipid Metabolism ; Mental Disorders/metabolism ; Nervous System Diseases/metabolism |
| مستخلص: | Lipids comprise the bulk of the dry mass of the brain. In addition to providing structural integrity to membranes, insulation to cells and acting as a source of energy, lipids can be rapidly converted to mediators of inflammation or to signaling molecules that control molecular and cellular events in the brain. The advent of soft ionization procedures such as electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI) have made it possible for compositional studies of the diverse lipid structures that are present in brain. These include phospholipids, ceramides, sphingomyelin, cerebrosides, cholesterol and their oxidized derivatives. Lipid analyses have delineated metabolic defects in disease conditions including mental retardation, Parkinson's Disease (PD), schizophrenia, Alzheimer's Disease (AD), depression, brain development, and ischemic stroke. In this review, we examine the structure of the major lipid classes in the brain, describe methods used for their characterization, and evaluate their role in neurological diseases. The potential utility of characterizing lipid markers in the brain, with specific emphasis on disease mechanisms, will be discussed. Additionally, we describe several proteomic strategies for characterizing lipid-metabolizing proteins in human cerebrospinal fluid (CSF). These proteins may be potential therapeutic targets since they transport lipids required for neuronal growth or convert lipids into molecules that control brain physiology. Combining lipidomics and proteomics will enhance existing knowledge of disease pathology and increase the likelihood of discovering specific markers and biochemical mechanisms of brain diseases. |
| Number of References: | 238 |
| معلومات مُعتمدة: | R01#11020991 United States PHS HHS |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cerebrospinal Fluid Proteins) 0 (Lipids) |
| تواريخ الأحداث: | Date Created: 20060118 Date Completed: 20060317 Latest Revision: 20190608 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC3851111 |
| DOI: | 10.1155/2006/202938 |
| PMID: | 16410651 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0278-0240 |
|---|---|
| DOI: | 10.1155/2006/202938 |