دورية أكاديمية
Intravesical adjuvant therapy using mitomycin C.
| العنوان: | Intravesical adjuvant therapy using mitomycin C. |
|---|---|
| المؤلفون: | Islam MA; BSMMU, Dhaka., Bhuiyan ZH, Shameem IA |
| المصدر: | Mymensingh medical journal : MMJ [Mymensingh Med J] 2006 Jan; Vol. 15 (1), pp. 40-4. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mymensingh Medical College Country of Publication: Bangladesh NLM ID: 9601799 Publication Model: Print Cited Medium: Print ISSN: 1022-4742 (Print) Linking ISSN: 10224742 NLM ISO Abbreviation: Mymensingh Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Mymensingh, Bangladesh : Mymensingh Medical College, |
| مواضيع طبية MeSH: | Antibiotics, Antineoplastic/*therapeutic use , Carcinoma, Transitional Cell/*drug therapy , Mitomycin/*therapeutic use , Urinary Bladder Neoplasms/*drug therapy, Administration, Intravesical ; Adult ; Aged ; Antibiotics, Antineoplastic/administration & dosage ; Chemotherapy, Adjuvant ; Female ; Humans ; Male ; Middle Aged ; Mitomycin/administration & dosage ; Neoplasm Recurrence, Local ; Risk Assessment ; Risk Factors |
| مستخلص: | Bladder cancer is mostly superficial at first diagnosis. High incidence of recurrence is the major problem after initial management with transurethral resection (TUR) of bladder tumor. Adjuvant chemotherapy has been advocated to reduce the incidence of recurrence. A study was carried out to observe the efficacy of intravesical adjuvant therapy with single immediate versus delayed multi-dose regimen of Mitomycin C (MMC) in preventing recurrence of superficial bladder cancer. One hundred Patients having intermediate risk superficial bladder cancer were randomized into two equal groups. All patients were followed carefully. Total duration of follow-up was minimum 12 months, maximum 36 months, mean 29 months. No recurrence was seen on 3(rd), 6(th) and 9(th) month of intravesical therapy. As much as 94% and 96% of recurrence free rate was observed in immediate single and delayed multi-dose group respectively on 12(th) month; 86% and 84% on 18(th) month; 74% and 72% on 24(th) month; 70% and 68% on 36(th) month of follow-up cystoscopy respectively. Efficacy of post transurethral resection of bladder tumour (TURBT) MMC single immediate dose was found similar to that of MMC delayed multi-dose regimen in preventing the recurrence of intermediate risk superficial bladder transitional cell carcinoma (TCC) in the study. The difference between the two groups insignificant (p>0.05). |
| المشرفين على المادة: | 0 (Antibiotics, Antineoplastic) 50SG953SK6 (Mitomycin) |
| تواريخ الأحداث: | Date Created: 20060210 Date Completed: 20060612 Latest Revision: 20191109 |
| رمز التحديث: | 20240628 |
| DOI: | 10.3329/mmj.v15i1.17 |
| PMID: | 16467761 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1022-4742 |
|---|---|
| DOI: | 10.3329/mmj.v15i1.17 |