دورية أكاديمية
Markers of cutaneous human papillomavirus infection in individuals with tumor-free skin, actinic keratoses, and squamous cell carcinoma.
| العنوان: | Markers of cutaneous human papillomavirus infection in individuals with tumor-free skin, actinic keratoses, and squamous cell carcinoma. |
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| المؤلفون: | Struijk L; Department of Medical Microbiology, Leiden University Medical Center, E4P, P.O. Box 9600, 2300 RC Leiden, the Netherlands. l.struijk@lumc.nl, Hall L, van der Meijden E, Wanningen P, Bavinck JN, Neale R, Green AC, Ter Schegget J, Feltkamp MC |
| المصدر: | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2006 Mar; Vol. 15 (3), pp. 529-35. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9200608 Publication Model: Print Cited Medium: Print ISSN: 1055-9965 (Print) Linking ISSN: 10559965 NLM ISO Abbreviation: Cancer Epidemiol Biomarkers Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : American Association for Cancer Research, c1991- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell/*epidemiology , DNA Probes, HPV/*analysis , Keratosis/*epidemiology , Papillomavirus Infections/*epidemiology , Skin Neoplasms/*epidemiology, Adult ; Age Distribution ; Aged ; Biomarkers/analysis ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/virology ; Case-Control Studies ; Comorbidity ; Confidence Intervals ; DNA, Viral/analysis ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Incidence ; Keratosis/pathology ; Keratosis/virology ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Papillomavirus Infections/diagnosis ; Prognosis ; Reference Values ; Risk Assessment ; Sensitivity and Specificity ; Sex Distribution ; Skin Neoplasms/pathology ; Skin Neoplasms/virology |
| مستخلص: | Separately, actinic keratosis (AK) and cutaneous squamous cell carcinoma (SCC) have been associated with cutaneous human papillomavirus (HPV) infections. To further explore the association between HPV infection and SCC development, we determined markers of cutaneous HPV infection within a single population in persons with precursor lesions (AK), cancerous lesions (SCC), and without. Serum and plucked eyebrow hairs were collected from 57 tumor-free controls, 126 AK, and 64 SCC cases. Presence of HPV L1 and E6 seroreactivity and viral DNA were determined for HPV types 5, 8, 15, 16, 20, 24, and 38. Significant positive associations with increasing severity of the lesions (controls, AK, and SCC, respectively) were observed for overall HPV L1 seropositivity (13%, 26%, and 37%) and for HPV8 (4%, 17%, and 30%). In parallel, the proportion of L1 seropositive individuals against multiple HPV types increased from 14% to 39% and 45%. The overall E6 seroreactivity, however, tended to decline with AK and SCC, especially for HPV8 (21%, 11%, and 2%). HPV DNA positivity was most prevalent in the AK cases (54%) compared with the SCC cases (44%) and the tumor-free controls (40%). Among all participants, there was a positive trend between overall HPV DNA positivity and L1 seropositivity, but not E6 seropositivity. Taken together, our data suggest that cutaneous HPV infections accompanied by detectable HPV DNA in eyebrow hairs and HPV L1 seropositivity, but not E6 seropositivity, are associated with an increased risk of AK and SCC. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (DNA Probes, HPV) 0 (DNA, Viral) |
| تواريخ الأحداث: | Date Created: 20060316 Date Completed: 20060719 Latest Revision: 20151119 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1158/1055-9965.EPI-05-0747 |
| PMID: | 16537712 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1055-9965 |
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| DOI: | 10.1158/1055-9965.EPI-05-0747 |