دورية أكاديمية
Significance of occult HBV infection in patients with chronic hepatitis C.
| العنوان: | Significance of occult HBV infection in patients with chronic hepatitis C. |
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| المؤلفون: | Anwar W; Department of Medicine, Military Hospital, Rawalpindi. wasifanwar_1973@hotmail.com, Sarwar M, Hussain AB, Tariq WU, Saif M |
| المصدر: | Journal of the College of Physicians and Surgeons--Pakistan : JCPSP [J Coll Physicians Surg Pak] 2006 Mar; Vol. 16 (3), pp. 192-5. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: College of Physicians and Surgeons Pakistan Country of Publication: Pakistan NLM ID: 9606447 Publication Model: Print Cited Medium: Print ISSN: 1022-386X (Print) Linking ISSN: 1022386X NLM ISO Abbreviation: J Coll Physicians Surg Pak Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Karachi : College of Physicians and Surgeons Pakistan, |
| مواضيع طبية MeSH: | Antiviral Agents/*therapeutic use , Hepatitis B/*epidemiology , Hepatitis C, Chronic/*complications , Hepatitis C, Chronic/*drug therapy , Interferons/*therapeutic use , Ribavirin/*therapeutic use, Adult ; Antiviral Agents/administration & dosage ; DNA, Viral/analysis ; Drug Therapy, Combination ; Follow-Up Studies ; Hepatitis B/diagnosis ; Hepatitis B virus/genetics ; Hepatitis C, Chronic/diagnosis ; Humans ; Interferons/administration & dosage ; Male ; Middle Aged ; Polymerase Chain Reaction ; Ribavirin/administration & dosage ; Time Factors ; Treatment Outcome |
| مستخلص: | Objective: To determine the frequency of occurrence of occult Hepatitis B infection in chronic hepatitis C patients and its impact (if any) on the effectivity of standard chronic hepatitis C treatment. Design: Quasi-experimental study. Place and Duration of Study: The study was conducted at the Department of Medicine, Military Hospital, Rawalpindi, and Virology Department, Armed Forces Institute of Pathology, Rawalpindi, for a period of nine months from January 2003 to September 2003. Patients and Methods: This study was conducted on 30 HBsAg negative patients with chronic hepatitis C liver disease who were receiving combination therapy with interferon and ribavirin. Occult hepatitis B infection was assessed by carrying out HBV DNA by polymerase chain reaction (PCR) in the sera of these patients. Markers of previous hepatitis B infection i.e; anti-HBs and total anti-HBc antibodies were also tested. Response to treatment for hepatitis C (with interferon and ribavirin) was assessed at the end of six months of therapy by measuring ALT levels and HCV RNA by PCR in the serum. Results: In our study only one patient (3.33%) was found to be harbouring HBV DNA in the serum detectable by PCR, with markers of previous HBV infection (both anti HBc antibodies and anti HBs antibodies were positive). A total 14 patients (46.67%) had markers of previous HBV infection, while 16 patients (53.33%) had no such seromarkers. Twenty-five out of 30 patients (83.33%) responded to treatment and 5 (16.66%) turned out to be non-responders. The single case of occult hepatitis B detected in this study responded to hepatitis C treatment. Conclusion: Occult hepatitis B is not a common occurrence in chronic hepatitis C patients and it did not alter the outcome of treatment for hepatitis C in our study. |
| المشرفين على المادة: | 0 (Antiviral Agents) 0 (DNA, Viral) 49717AWG6K (Ribavirin) 9008-11-1 (Interferons) |
| تواريخ الأحداث: | Date Created: 20060318 Date Completed: 20070104 Latest Revision: 20140729 |
| رمز التحديث: | 20221213 |
| DOI: | 3.2006/JCPSP.192195 |
| PMID: | 16542598 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1022-386X |
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| DOI: | 3.2006/JCPSP.192195 |