دورية أكاديمية
Malignant transformation of posterior fossa epidermoid cyst.
| العنوان: | Malignant transformation of posterior fossa epidermoid cyst. |
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| المؤلفون: | Michael LM 2nd; Department of Neurosurgery, University of Tennessee at Memphis, Memphis, Tennessee 38120, USA. lmmichael2@pol.net, Moss T, Madhu T, Coakham HB |
| المصدر: | British journal of neurosurgery [Br J Neurosurg] 2005 Dec; Vol. 19 (6), pp. 505-10. |
| نوع المنشور: | Case Reports; Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: England NLM ID: 8800054 Publication Model: Print Cited Medium: Print ISSN: 0268-8697 (Print) Linking ISSN: 02688697 NLM ISO Abbreviation: Br J Neurosurg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015-: Abingdon, Oxfordshire : Taylor & Francis Original Publication: Abingdon, Oxfordshire : Carfax Pub. Co., c1987- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell/*secondary , Cell Transformation, Neoplastic/*pathology , Epidermal Cyst/*pathology , Meningeal Neoplasms/*secondary, Cranial Fossa, Posterior/pathology ; Fatal Outcome ; Humans ; Magnetic Resonance Imaging ; Male |
| مستخلص: | The authors report the case of a 45-year-old man who presented with a short duration of a painful ophthalmoparesis. Initial magnetic resonance imaging revealed an extraaxial petroclival mass characteristic of an epidermoid cyst, with the exception of a contiguous contrast-enhancing lobule. A subtotal resection was performed with the histopathological diagnosis revealing malignant transformation of an epidermoid cyst. Despite aggressive postoperative adjuvant therapy, the patient developed leptomeningeal metastasis and died shortly thereafter. The presence of contrast enhancement at the site of an epidermoid cyst combined with an acute, progressive neurological deficit should alert the treating physician to the possibility of a malignant transformation. When transformation does occur, the clinical and radiological course is quite aggressive as compared with the indolent growth of epidermoid cysts. Treatment options include surgery with adjuvant chemotherapy or radiotherapy. We review the pertinent features of this case along with the relevant literature regarding primary intracranial squamous cell carcinomas. |
| Number of References: | 46 |
| تواريخ الأحداث: | Date Created: 20060401 Date Completed: 20060824 Latest Revision: 20220419 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/02688690500495356 |
| PMID: | 16574566 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0268-8697 |
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| DOI: | 10.1080/02688690500495356 |