دورية أكاديمية
أعرض في EDS

Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.

التفاصيل البيبلوغرافية
العنوان: Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications.
المؤلفون: Nathan D; Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, Pennsylvania 19104, USA., Ingvarsdottir K, Sterner DE, Bylebyl GR, Dokmanovic M, Dorsey JA, Whelan KA, Krsmanovic M, Lane WS, Meluh PB, Johnson ES, Berger SL
المصدر: Genes & development [Genes Dev] 2006 Apr 15; Vol. 20 (8), pp. 966-76. Date of Electronic Publication: 2006 Apr 05.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0890-9369 (Print) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE
أسماء مطبوعة: Publication: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press
Original Publication: [Cold Spring Harbor, N.Y.] : Cold Spring Harbor Laboratory in association with the Genetical Society of Great Britain, [c1987-
مواضيع طبية MeSH: Histones/*metabolism , SUMO-1 Protein/*metabolism , Saccharomyces cerevisiae/*metabolism, Acetylation ; Amino Acid Sequence ; Blotting, Western ; Immunoprecipitation ; Protein Processing, Post-Translational ; Saccharomyces cerevisiae/genetics ; Telomere ; Ubiquitin/metabolism
مستخلص: Covalent histone post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitylation play pivotal roles in regulating many cellular processes, including transcription, response to DNA damage, and epigenetic control. Although positive-acting post-translational modifications have been studied in Saccharomyces cerevisiae, histone modifications that are associated with transcriptional repression have not been shown to occur in this yeast. Here, we provide evidence that histone sumoylation negatively regulates transcription in S. cerevisiae. We show that all four core histones are sumoylated and identify specific sites of sumoylation in histones H2A, H2B, and H4. We demonstrate that histone sumoylation sites are involved directly in transcriptional repression. Further, while histone sumoylation occurs at all loci tested throughout the genome, slightly higher levels occur proximal to telomeres. We observe a dynamic interplay between histone sumoylation and either acetylation or ubiquitylation, where sumoylation serves as a potential block to these activating modifications. These results indicate that sumoylation is the first negative histone modification to be identified in S. cerevisiae and further suggest that sumoylation may serve as a general dynamic mark to oppose transcription.
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معلومات مُعتمدة: R01 GM060464 United States GM NIGMS NIH HHS; U54 RR020839 United States RR NCRR NIH HHS; GM60464 United States GM NIGMS NIH HHS; GM62268 United States GM NIGMS NIH HHS; GM55360 United States GM NIGMS NIH HHS; R01 GM055360 United States GM NIGMS NIH HHS; R01 GM062268 United States GM NIGMS NIH HHS; RR020839 United States RR NCRR NIH HHS
المشرفين على المادة: 0 (Histones)
0 (SUMO-1 Protein)
0 (Ubiquitin)
تواريخ الأحداث: Date Created: 20060407 Date Completed: 20060623 Latest Revision: 20181113
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC1472304
DOI: 10.1101/gad.1404206
PMID: 16598039
قاعدة البيانات: MEDLINE
الوصف
تدمد:0890-9369
DOI:10.1101/gad.1404206