دورية أكاديمية
Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination.
| العنوان: | Expression of discoidin domain receptor 1 during mouse brain development follows the progress of myelination. |
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| المؤلفون: | Franco-Pons N; Unitat de Psiquiatria i Psicologia Mèdica, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, and Departament de Formació i Investigació, Hospital Psiquiàtric Universitari Institut Pere Mata, Reus, Spain., Virgos C, Vogel WF, Ureña JM, Soriano E, del Rio JA, Vilella E |
| المصدر: | Neuroscience [Neuroscience] 2006 Jun 30; Vol. 140 (2), pp. 463-75. Date of Electronic Publication: 2006 Apr 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0306-4522 (Print) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: [New York?] : Elsevier Science Original Publication: Oxford, Elmsford, N. Y., Pergamon Press |
| مواضيع طبية MeSH: | Brain/*embryology , Brain/*growth & development , Cell Differentiation/*physiology , Myelin Sheath/*metabolism , Nerve Fibers, Myelinated/*metabolism , Receptor Protein-Tyrosine Kinases/*metabolism , Receptors, Mitogen/*metabolism, Adenomatous Polyposis Coli Protein/metabolism ; Animals ; Animals, Newborn ; Biomarkers/metabolism ; Brain/metabolism ; Carnosine/metabolism ; Cell Proliferation ; Discoidin Domain Receptors ; Embryonic Development/physiology ; Mice ; Myelin Sheath/ultrastructure ; Nerve Fibers, Myelinated/ultrastructure ; Neuroglia/metabolism ; Neurons/metabolism ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; RNA, Messenger/metabolism ; Receptor Protein-Tyrosine Kinases/genetics ; Receptors, Mitogen/genetics |
| مستخلص: | Discoidin domain receptor 1 is a tyrosine kinase receptor expressed in a variety of tissues including the brain. This study describes mRNA and protein expression of discoidin domain receptor 1 in mouse brain during development and provides new insights into its role during gliogenesis and neurogenesis. We performed in situ hybridization for discoidin domain receptor 1 in mouse brains at embryonic day 18, postnatal days 5, 9, 15, 21 and adulthood and observed a diffuse pattern in the proliferative areas during embryogenesis. From postnatal day 5 onwards, a defined cellular expression pattern of discoidin domain receptor 1 was observed, mainly located in white matter tracts and following a spatio-temporal pattern that overlapped the progress of myelination. Next, we performed double-labeling reactions (in situ hybridization followed by immunohistochemistry) that confirmed that discoidin domain receptor 1 was expressed by mature oligodendrocytes. We observed that cells positive for discoidin domain receptor 1 also expressed carnosine and anti-adenomatous polyposis coli, two mature oligodendrocyte markers. Based on the localization of discoidin domain receptor 1 specifically in the white matter fiber tracts during postnatal development, we suggest that discoidin domain receptor 1 participates in the development and maintenance of the myelin sheath. |
| المشرفين على المادة: | 0 (Adenomatous Polyposis Coli Protein) 0 (Biomarkers) 0 (RNA, Messenger) 0 (Receptors, Mitogen) 8HO6PVN24W (Carnosine) EC 2.7.10.1 (Discoidin Domain Receptors) EC 2.7.10.1 (Receptor Protein-Tyrosine Kinases) |
| تواريخ الأحداث: | Date Created: 20060411 Date Completed: 20060925 Latest Revision: 20161128 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.neuroscience.2006.02.033 |
| PMID: | 16603319 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0306-4522 |
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| DOI: | 10.1016/j.neuroscience.2006.02.033 |