Hepatitis C virus carriers with persistently normal ALT levels: biological peculiarities and update of the natural history of liver disease at 10 years.

التفاصيل البيبلوغرافية
العنوان:	Hepatitis C virus carriers with persistently normal ALT levels: biological peculiarities and update of the natural history of liver disease at 10 years.
المؤلفون:	Persico M; Internal Medicine and Hepatology Unit, Second University of Naples, Naples, Italy. marcello.persico@unina2.it, Perrotta S, Persico E, Terracciano L, Folgori A, Ruggeri L, Nicosia A, Vecchione R, Mura VL, Masarone M, Torella R
المصدر:	Journal of viral hepatitis [J Viral Hepat] 2006 May; Vol. 13 (5), pp. 290-6.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print Cited Medium: Print ISSN: 1352-0504 (Print) Linking ISSN: 13520504 NLM ISO Abbreviation: J Viral Hepat Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Oxford ; Boston : Blackwell Scientific Publications, 1994-
مواضيع طبية MeSH:	Alanine Transaminase/blood , Hepacivirus/growth & development , Hepatitis C, Chronic/enzymology , Hepatitis C, Chronic/pathology, Adult ; Aged ; Biopsy, Needle ; Carrier State/enzymology ; Carrier State/virology ; Cohort Studies ; Disease Progression ; Enzyme-Linked Immunosorbent Assay ; Female ; Genotype ; Hepatitis C, Chronic/immunology ; Humans ; Immunohistochemistry ; Interferon-gamma/blood ; Liver/metabolism ; Liver/pathology ; Male ; Middle Aged ; Proliferating Cell Nuclear Antigen/metabolism ; RNA, Viral/chemistry ; RNA, Viral/genetics ; Reverse Transcriptase Polymerase Chain Reaction
مستخلص:	Some chronic hepatitis C (CHC) patients exhibit persistently normal alanine aminotransferase (ALT) levels (PNAL). Patients with PNAL experience significantly milder disease. In order to understand the differences between CHC patients with elevated ALT levels compared with those with PNAL better, we compared epidemiological, immunological and histological findings, in particular, the value of proliferating hepatocyte activity (PCNA) between the two groups of patients. We studied 40 chronic hepatitis C virus (HCV) carriers with increased ALT who underwent liver biopsy for histological diagnosis and determination of clinical prognosis, and 24 PNAL patients under follow-up for 10 years. Immunological response to different HCV genomic epitopes was tested in both the control group and in PNAL subjects. PCNA values from liver specimens of all patients as well as liver biopsies of PNAL patients at time points 0 and 5 years were calculated according to Hall et al.Age, sex and body mass index (BMI) were not significantly different between the two groups. The median liver histology stage was significantly higher in HCV carriers vs the PNAL group (2.5, range = 2-6 vs 1.5, range = 1-2; P < 0.01). Among PNAL patients, histological stage was not statistically different at the three time points considered. Interferon (IFN)-gamma production was comparable in the two groups. PCNA was significantly higher in the group with elevated ALT levels vs the PNAL group (8%, range = 4-15%vs 5% range = 3-8%; P < 0.05) and no statistically significant differences were found in PNAL patients at time points 0, 5 and 10 years. This study confirms that progression to cirrhosis is slow or absent in PNAL patients after 10 years of follow-up. Accordingly, the hepatic proliferative activity index is low and seems to be stable over time.
التعليقات:	Comment in: J Viral Hepat. 2006 May;13(5):289. (PMID: 16637857)
المشرفين على المادة:	0 (Proliferating Cell Nuclear Antigen) 0 (RNA, Viral) 82115-62-6 (Interferon-gamma) EC 2.6.1.2 (Alanine Transaminase)
تواريخ الأحداث:	Date Created: 20060428 Date Completed: 20060629 Latest Revision: 20211203
رمز التحديث:	20221213
DOI:	10.1111/j.1365-2893.2005.00667.x
PMID:	16637858
قاعدة البيانات:	MEDLINE

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تدمد:	1352-0504
DOI:	10.1111/j.1365-2893.2005.00667.x