دورية أكاديمية
Are Plasmodium falciparum parasites present in peripheral blood genetically the same as those sequestered in the tissues?
| العنوان: | Are Plasmodium falciparum parasites present in peripheral blood genetically the same as those sequestered in the tissues? |
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| المؤلفون: | Dembo EG; Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Phiri HT, Montgomery J, Molyneux ME, Rogerson SJ |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2006 May; Vol. 74 (5), pp. 730-2. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print Cited Medium: Print ISSN: 0002-9637 (Print) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Malaria, Falciparum/*parasitology , Plasmodium falciparum/*genetics, Animals ; Antigens, Protozoan/genetics ; Child ; Child, Preschool ; DNA, Protozoan/analysis ; Female ; Genotype ; Humans ; Infant ; Infant, Newborn ; Malaria, Falciparum/blood ; Malaria, Falciparum/epidemiology ; Malaria, Falciparum/etiology ; Malaria, Falciparum/pathology ; Malawi/epidemiology ; Male ; Merozoite Surface Protein 1/genetics ; Polymerase Chain Reaction ; Protozoan Proteins/genetics ; Severity of Illness Index |
| مستخلص: | Since quinine does not inhibit the growth of Plasmodium falciparum ring stages or mature schizonts, parasites may continue to emerge from sequestration sites after starting treatment. We used polymerase chain reaction amplification of P. falciparum merozoite surface protein 1 (MSP-1) and MSP-2 alleles to distinguish genotypes infecting 58 children with severe malaria. To examine changes in parasite populations in peripheral blood over time, we compared changes in number and spectrum of genotypes in samples on admission to a hospital to those obtained up to 24 hours later. Thirty-four children lost genotypes, 21 retained genotypes, and 3 gained an extra P. falciparum genotype at one locus but not the other. The lack of novel genotypes emerging suggests that among children with severe malaria the dominant clones sequestered in deep organs are usually the same as those in peripheral circulation. |
| معلومات مُعتمدة: | 063215 United Kingdom Wellcome Trust; 071376 United Kingdom Wellcome Trust |
| المشرفين على المادة: | 0 (Antigens, Protozoan) 0 (DNA, Protozoan) 0 (Merozoite Surface Protein 1) 0 (Protozoan Proteins) 0 (merozoite surface protein 2, Plasmodium) |
| تواريخ الأحداث: | Date Created: 20060512 Date Completed: 20060615 Latest Revision: 20070813 |
| رمز التحديث: | 20231215 |
| PMID: | 16687670 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0002-9637 |
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