دورية أكاديمية
أعرض في EDS

Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination.

التفاصيل البيبلوغرافية
العنوان: Disparate requirements for the Walker A and B ATPase motifs of human RAD51D in homologous recombination.
المؤلفون: Wiese C; Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. cwiese@lbl.gov, Hinz JM, Tebbs RS, Nham PB, Urbin SS, Collins DW, Thompson LH, Schild D
المصدر: Nucleic acids research [Nucleic Acids Res] 2006 May 22; Vol. 34 (9), pp. 2833-43. Date of Electronic Publication: 2006 May 22 (Print Publication: 2006).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
أسماء مطبوعة: Publication: 1992- : Oxford : Oxford University Press
Original Publication: London, Information Retrieval ltd.
مواضيع طبية MeSH: Recombination, Genetic*, Adenosine Triphosphatases/*chemistry , DNA-Binding Proteins/*chemistry, Amino Acid Motifs ; Amino Acid Sequence ; Animals ; CHO Cells ; Cricetinae ; Cricetulus ; DNA Damage ; DNA Repair ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Genetic Complementation Test ; Humans ; Immunoprecipitation ; Molecular Sequence Data ; Mutation ; Rad51 Recombinase/metabolism ; Two-Hybrid System Techniques
مستخلص: In vertebrates, homologous recombinational repair (HRR) requires RAD51 and five RAD51 paralogs (XRCC2, XRCC3, RAD51B, RAD51C and RAD51D) that all contain conserved Walker A and B ATPase motifs. In human RAD51D we examined the requirement for these motifs in interactions with XRCC2 and RAD51C, and for survival of cells in response to DNA interstrand crosslinks (ICLs). Ectopic expression of wild-type human RAD51D or mutants having a non-functional A or B motif was used to test for complementation of a rad51d knockout hamster CHO cell line. Although A-motif mutants complement very efficiently, B-motif mutants do not. Consistent with these results, experiments using the yeast two- and three-hybrid systems show that the interactions between RAD51D and its XRCC2 and RAD51C partners also require a functional RAD51D B motif, but not motif A. Similarly, hamster Xrcc2 is unable to bind to the non-complementing human RAD51D B-motif mutants in co-immunoprecipitation assays. We conclude that a functional Walker B motif, but not A motif, is necessary for RAD51D's interactions with other paralogs and for efficient HRR. We present a model in which ATPase sites are formed in a bipartite manner between RAD51D and other RAD51 paralogs.
References: J Biol Chem. 2000 Jun 2;275(22):16443-9. (PMID: 10749867)
J Biol Chem. 2000 Sep 15;275(37):29100-6. (PMID: 10871607)
Mol Cell Biol. 2001 Apr;21(8):2858-66. (PMID: 11283264)
Proc Natl Acad Sci U S A. 2001 May 8;98(10):5538-43. (PMID: 11331762)
Mutat Res. 2001 Jun 2;477(1-2):131-53. (PMID: 11376695)
J Biol Chem. 2001 Jun 22;276(25):22148-53. (PMID: 11301337)
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8440-6. (PMID: 11459987)
Genes Dev. 2001 Dec 15;15(24):3296-307. (PMID: 11751635)
Genes Dev. 2001 Dec 15;15(24):3308-18. (PMID: 11751636)
Methods Enzymol. 2002;344:617-31. (PMID: 11771415)
Nucleic Acids Res. 2002 Feb 15;30(4):1001-8. (PMID: 11842112)
Nucleic Acids Res. 2002 Feb 15;30(4):1009-15. (PMID: 11842113)
J Biol Chem. 2002 Mar 8;277(10):8406-11. (PMID: 11744692)
J Biol Chem. 2002 Apr 19;277(16):14315-20. (PMID: 11834724)
J Biol Chem. 2002 Jun 7;277(23):20185-94. (PMID: 11923292)
Mol Cell. 2002 Aug;10(2):387-95. (PMID: 12191483)
J Biol Chem. 2003 Jan 24;278(4):2469-78. (PMID: 12427746)
Structure. 2003 Feb;11(2):187-96. (PMID: 12575938)
Hum Mol Genet. 2003 Apr 15;12(8):915-23. (PMID: 12668615)
Mol Cell Biol. 2003 Aug;23(16):5706-15. (PMID: 12897142)
EMBO J. 2003 Sep 1;22(17):4566-76. (PMID: 12941707)
J Biol Chem. 2003 Nov 14;278(46):45445-50. (PMID: 12966089)
J Biol Chem. 2003 Nov 28;278(48):48357-66. (PMID: 12975363)
Mutat Res. 2003 Nov 27;532(1-2):103-15. (PMID: 14643432)
Science. 2004 Jan 9;303(5655):243-6. (PMID: 14716019)
Nucleic Acids Res. 2004;32(8):2556-65. (PMID: 15141025)
J Biol Chem. 2004 May 28;279(22):23250-4. (PMID: 15037616)
J Biol Chem. 2004 Jul 16;279(29):30385-94. (PMID: 15123651)
DNA Repair (Amst). 2004 Aug-Sep;3(8-9):863-73. (PMID: 15279771)
Nat Struct Mol Biol. 2004 Aug;11(8):791-6. (PMID: 15235592)
Mol Cell. 2004 Aug 13;15(3):423-35. (PMID: 15304222)
DNA Repair (Amst). 2004 Oct 5;3(10):1363-74. (PMID: 15336631)
J Biol Chem. 2004 Oct 1;279(40):42313-20. (PMID: 15292210)
J Cell Biochem. 2004 Oct 15;93(3):429-36. (PMID: 15372620)
EMBO J. 1982;1(8):945-51. (PMID: 6329717)
Gene. 1987;52(2-3):225-33. (PMID: 3038686)
Nature. 1992 Jan 23;355(6358):318-25. (PMID: 1731246)
Nucleic Acids Res. 1992 Jun 11;20(11):2902. (PMID: 1614888)
Methods Enzymol. 1995;254:241-63. (PMID: 8531690)
Biochimie. 1999 Jan-Feb;81(1-2):87-105. (PMID: 10214914)
Trends Genet. 1999 May;15(5):166-8. (PMID: 10322480)
Mol Cell Biol. 1999 Oct;19(10):6891-7. (PMID: 10490626)
J Biol Chem. 2005 Jan 7;280(1):722-8. (PMID: 15537659)
Mol Cell Biol. 2005 Feb;25(3):1124-34. (PMID: 15657438)
Cancer Lett. 2005 Mar 10;219(2):125-35. (PMID: 15723711)
J Pharmacol Exp Ther. 2005 Aug;314(2):495-505. (PMID: 15843498)
Nucleic Acids Res. 2005;33(14):4544-52. (PMID: 16093548)
Mol Microbiol. 2005 Oct;58(2):358-66. (PMID: 16194225)
Biochemistry. 2005 Oct 25;44(42):13753-61. (PMID: 16229465)
Mutagenesis. 2005 Nov;20(6):433-40. (PMID: 16236763)
EMBO J. 2006 Jan 11;25(1):222-31. (PMID: 16395335)
DNA Repair (Amst). 2006 Mar 7;5(3):381-91. (PMID: 16388992)
Nucleic Acids Res. 2006;34(5):1358-68. (PMID: 16522646)
Hum Mol Genet. 2006 Apr 1;15(7):1217-24. (PMID: 16505003)
معلومات مُعتمدة: CA112566 United States CA NCI NIH HHS; R01 CA112566 United States CA NCI NIH HHS; CA89405 United States CA NCI NIH HHS; P01 CA092584 United States CA NCI NIH HHS; P01 CA92584 United States CA NCI NIH HHS; R01 CA089405 United States CA NCI NIH HHS
المشرفين على المادة: 0 (DNA-Binding Proteins)
0 (RAD51D protein, human)
EC 2.7.7.- (Rad51 Recombinase)
EC 3.6.1.- (Adenosine Triphosphatases)
تواريخ الأحداث: Date Created: 20060524 Date Completed: 20060607 Latest Revision: 20181113
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC1464408
DOI: 10.1093/nar/gkl366
PMID: 16717288
قاعدة البيانات: MEDLINE
الوصف
تدمد:1362-4962
DOI:10.1093/nar/gkl366