دورية أكاديمية
Lymphatic microvessel density as prognostic marker in colorectal cancer.
| العنوان: | Lymphatic microvessel density as prognostic marker in colorectal cancer. |
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| المؤلفون: | Saad RS; Department of Pathology, Allegheny General Hospital/Drexel University College of Medicine, Pittsburgh, PA 15213, USA. rsaad@wpahs.org, Kordunsky L, Liu YL, Denning KL, Kandil HA, Silverman JF |
| المصدر: | Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2006 Oct; Vol. 19 (10), pp. 1317-23. Date of Electronic Publication: 2006 Jun 23. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 8806605 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0893-3952 (Print) Linking ISSN: 08933952 NLM ISO Abbreviation: Mod Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Inc. Original Publication: Baltimore, MD : Williams & Wilkins, c1988- |
| مواضيع طبية MeSH: | Biomarkers, Tumor/*analysis , Colorectal Neoplasms/*pathology , Liver Neoplasms/*secondary , Lymphatic Vessels/*pathology, Adult ; Aged ; Aged, 80 and over ; Antibodies, Monoclonal/analysis ; Antibodies, Monoclonal, Murine-Derived ; Antigens, Neoplasm/analysis ; Colorectal Neoplasms/chemistry ; Female ; Humans ; Lymphatic Metastasis ; Lymphatic Vessels/chemistry ; Male ; Middle Aged ; Neoplasm Invasiveness ; Platelet Endothelial Cell Adhesion Molecule-1/analysis ; Prognosis ; Retrospective Studies ; Vascular Endothelial Growth Factor A/analysis |
| مستخلص: | Lymph node metastases is an important prognostic indicator for disease progression and crucial for therapeutic strategies in the work-up of colorectal carcinoma. In this study, we investigated tumor lymphangiogenesis and vascular endothelial growth factor (VEGF) expression as predictive markers for the risk of lymph node metastasis and their relation to other prognostic parameters in colorectal carcinoma. Resected colorectal carcinomas from 90 patients were examined, including 30 patients without lymph node metastases, 30 with only lymph node metastases, and 30 with liver metastases. Cases were immunostained for CD31, D2-40, and VEGF. Positivity stained microvessels were counted in densely vascular/lymphatic foci (hot spots) at x 400 field (=0.17 mm2). Intensity of staining for VEGF was scored on a two-tiered scale. D2-40 lymphatic microvessel density demonstrated significant correlation with CD31 counts (20+/-9 vs 18+/-6/0.17 mm2 field, P<0.05) and VEGF expression (P<0.01). VEGF was expressed in 61/90 (67%) cases. D2-40 identified lymphatic tumor invasion in 48/90 patients, which was greater than CD31 (37/90) and hematoxylin and eosin (H&E) (31/90). There was a positive significant correlation of D2-40, CD31 counts, and VEGF expression with the presence of lymphovascular invasion and lymph node metastases (P<0.05). D2-40 lymphatic microvessel density correlated significantly with depth of invasion (pT), positive vascular pedicle lymph nodes and liver metastases (P<0.05). In conclusion, D2-40 lymphatic microvessel density showed prognostic significance with positive correlation with lymphovascular invasion, pT, and metastases to lymph nodes and liver. Immunostaining with D2-40 enhances the detection of lymphatic invasion relative to H&E staining and the endothelial marker, CD31. |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Antibodies, Monoclonal, Murine-Derived) 0 (Antigens, Neoplasm) 0 (Biomarkers, Tumor) 0 (Platelet Endothelial Cell Adhesion Molecule-1) 0 (VEGFA protein, human) 0 (Vascular Endothelial Growth Factor A) 0 (monoclonal antibody D2-40) 0 (oncofetal antigens) |
| تواريخ الأحداث: | Date Created: 20060627 Date Completed: 20061113 Latest Revision: 20230210 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1038/modpathol.3800651 |
| PMID: | 16799477 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0893-3952 |
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| DOI: | 10.1038/modpathol.3800651 |