دورية أكاديمية
Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies.
| العنوان: | Effect of paroxetine, a selective 5-hydroxytryptamine uptake inhibitor, on beta-adrenoceptors in rat brain: autoradiographic and functional studies. |
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| المؤلفون: | Nelson DR; SmithKline Beecham Pharmaceuticals, Research and Development, Harlow, Essex., Pratt GD, Palmer KJ, Johnson AM, Bowery NG |
| المصدر: | Neuropharmacology [Neuropharmacology] 1991 Jun; Vol. 30 (6), pp. 607-16. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print Cited Medium: Print ISSN: 0028-3908 (Print) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Pergamon Press Original Publication: Oxford, New York, Pergamon. |
| مواضيع طبية MeSH: | Brain Chemistry/*drug effects , Piperidines/*pharmacology , Receptors, Adrenergic, beta/*drug effects , Serotonin Antagonists/*pharmacology, Adrenergic beta-Antagonists/pharmacology ; Amitriptyline/pharmacology ; Animals ; Autoradiography ; Cyclic AMP/metabolism ; Desipramine/pharmacology ; Iodine Radioisotopes ; Iodocyanopindolol ; Kinetics ; Male ; Membranes/drug effects ; Membranes/metabolism ; Paroxetine ; Pindolol/analogs & derivatives ; Propanolamines/pharmacology ; Rats ; Rats, Inbred Strains |
| مستخلص: | Quantitative receptor autoradiography was used to investigate the effects of paroxetine (8.3 mg/kg), amitriptyline (26 mg/kg) and desipramine (17 mg/kg), administered daily in the drinking water for 21 days, on the number of beta 1- and beta 2-adrenoceptors in the cortex of the rat. In addition, the effect of these drugs on the function of beta-adrenoceptors was examined by measuring noradrenaline- and isoprenaline-stimulated production of cyclic AMP in slices of cortex. Paroxetine did not alter the number of cortical beta 1 or beta 2-adrenoceptors nor did it induce any functional changes in beta-adrenoceptor-linked adenylyl cyclase. In contrast, desipramine caused a significant reduction in the density of beta 1-adrenoceptors and in the sensitivity of both noradrenaline and isoprenaline-stimulated adenylyl cyclase. Although amitriptyline significantly reduced the number of beta 1-adrenoceptors in cortical membranes, no such changes could be detected by autoradiography. It is apparent from these and other studies, that the ability of antidepressants to down-regulate central beta-adrenoceptors is not a property shared by all antidepressants. In particular, the more potent and selective inhibitors of the uptake of 5-HT, such as paroxetine, appear to be devoid of effects on this receptor system. |
| المشرفين على المادة: | 0 (Adrenergic beta-Antagonists) 0 (Iodine Radioisotopes) 0 (Piperidines) 0 (Propanolamines) 0 (Receptors, Adrenergic, beta) 0 (Serotonin Antagonists) 1806D8D52K (Amitriptyline) 41VRH5220H (Paroxetine) 83498-72-0 (Iodocyanopindolol) BJ4HF6IU1D (Pindolol) E0399OZS9N (Cyclic AMP) R89UMZ82MJ (CGP 12177) TG537D343B (Desipramine) |
| تواريخ الأحداث: | Date Created: 19910601 Date Completed: 19911031 Latest Revision: 20190726 |
| رمز التحديث: | 20240627 |
| DOI: | 10.1016/0028-3908(91)90080-u |
| PMID: | 1681445 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0028-3908 |
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| DOI: | 10.1016/0028-3908(91)90080-u |