دورية أكاديمية
Estrous cycle-dependent changes in basal and ethanol-induced activity of cortical dopaminergic neurons in the rat.
العنوان: | Estrous cycle-dependent changes in basal and ethanol-induced activity of cortical dopaminergic neurons in the rat. |
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المؤلفون: | Dazzi L; Department of Experimental Biology B. Loddo, University of Cagliari, Cagliari, Italy. dazzi@unica.it, Seu E, Cherchi G, Barbieri PP, Matzeu A, Biggio G |
المصدر: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology [Neuropsychopharmacology] 2007 Apr; Vol. 32 (4), pp. 892-901. Date of Electronic Publication: 2006 Jul 12. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8904907 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0893-133X (Print) Linking ISSN: 0893133X NLM ISO Abbreviation: Neuropsychopharmacology Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2003- : London : Nature Publishing Group Original Publication: [New York, NY] : Elsevier, [c1987- |
مواضيع طبية MeSH: | Central Nervous System Depressants/*pharmacology , Cerebral Cortex/*cytology , Estrous Cycle/*physiology , Ethanol/*pharmacology , Neurons/*drug effects, Animals ; Dopamine/metabolism ; Drug Interactions ; Enzyme Inhibitors/pharmacology ; Female ; Finasteride/pharmacology ; Microdialysis/methods ; Neurons/metabolism ; Ovariectomy/methods ; Progesterone/pharmacology ; Progestins/pharmacology ; Rats ; Rats, Sprague-Dawley |
مستخلص: | The influence of the estrous cycle on dopamine levels in the rat medial prefrontal cortex under basal and ethanol-stimulated conditions was evaluated by microdialysis. The basal dopamine concentration in the dialysate varied markedly during the estrous cycle, being highest in estrus and lowest in proestrus. Furthermore, a challenge intraperitoneal administration of ethanol (0.5 g/kg) induced a significant increase in dopaminergic output (+50%) during estrus but had no effect in diestrus or proestrus. Ovariectomy or pretreatment with either finasteride (a 5alpha-reductase inhibitor) or clomiphene (an estrogen receptor antagonist) prevented this ethanol-induced increase in dopamine concentration. The effect of ethanol was restored in ovariectomized rats by pretreatment with estrogen but not by that with progesterone. Our results thus show that the basal levels of dopamine in the prefrontal cortex are dependent on the phase of the estrous cycle. Furthermore, this dependence appears to be attributable to the effects of ovarian steroid hormones and results in a differential sensitivity of the dopaminergic neurons to ethanol. The hormone-induced changes in the activity of these neurons might contribute to the differences in drug sensitivity and mood state apparent among phases of the estrous cycle and between the sexes. |
معلومات مُعتمدة: | U01AA13641 United States AA NIAAA NIH HHS |
المشرفين على المادة: | 0 (Central Nervous System Depressants) 0 (Enzyme Inhibitors) 0 (Progestins) 3K9958V90M (Ethanol) 4G7DS2Q64Y (Progesterone) 57GNO57U7G (Finasteride) VTD58H1Z2X (Dopamine) |
تواريخ الأحداث: | Date Created: 20060715 Date Completed: 20070501 Latest Revision: 20220410 |
رمز التحديث: | 20231215 |
DOI: | 10.1038/sj.npp.1301150 |
PMID: | 16841076 |
قاعدة البيانات: | MEDLINE |
تدمد: | 0893-133X |
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DOI: | 10.1038/sj.npp.1301150 |