دورية أكاديمية
أعرض في EDS

A comparison of Tl-201, Tc-99m sestamibi, and Tc-99m tetrofosmin myocardial perfusion scintigraphy in patients with mild to moderate coronary stenosis.

التفاصيل البيبلوغرافية
العنوان: A comparison of Tl-201, Tc-99m sestamibi, and Tc-99m tetrofosmin myocardial perfusion scintigraphy in patients with mild to moderate coronary stenosis.
المؤلفون: Reyes E; National Heart and Lung Institute, Imperial College London, London, United Kingdom. e.reyes@rbh.nthames.nhs.uk, Loong CY, Harbinson M, Rahman S, Prvulovich E, Ell PJ, Anagnostopoulos C, Underwood SR
المصدر: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2006 Jul; Vol. 13 (4), pp. 488-94.
نوع المنشور: Evaluation Study; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society of Nuclear Cardiology Country of Publication: United States NLM ID: 9423534 Publication Model: Print Cited Medium: Internet ISSN: 1532-6551 (Electronic) Linking ISSN: 10713581 NLM ISO Abbreviation: J Nucl Cardiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2024- : New York : Elsevier Inc. on behalf of American Society of Nuclear Cardiology
Original Publication: St. Louis, MO : Mosby-Year Book, Inc., c1994-
مواضيع طبية MeSH: Organophosphorus Compounds* , Organotechnetium Compounds* , Technetium Tc 99m Sestamibi* , Thallium*, Coronary Stenosis/*diagnostic imaging, Female ; Humans ; Male ; Middle Aged ; Radionuclide Imaging ; Radiopharmaceuticals ; Reproducibility of Results ; Retrospective Studies ; Sensitivity and Specificity ; Severity of Illness Index
مستخلص: Background: Thallium 201, technetium 99m sestamibi (MIBI), and Tc-99m tetrofosmin differ in their myocardial uptake characteristics. This may make the technetium tracers less sensitive for detecting mild to moderate coronary stenosis.
Methods and Results: We identified 163 patients with angiographic mild to moderate stenosis (50%-89%) and coexistent severe disease (88/163 patients) from a previous study of patients who received either thallium, MIBI, or tetrofosmin for myocardial perfusion scintigraphy. Summed segmental uptake scores were used to assess myocardial perfusion of territories supplied by the mildly to moderately stenotic vessels. Mean (+/- SD) summed stress uptake scores in the left anterior descending artery territory were 21.4 +/- 3.8, 21.6 +/- 4.2, and 22.1 +/- 2.3 for thallium, MIBI, and tetrofosmin, respectively (P = .7); mean summed difference uptake scores were 1.2 +/- 1.8, 1.1 +/- 1.9, and 1.0 +/- 1.1, respectively (P = .8). In the non-left anterior descending artery territory, mean summed stress uptake scores were 32.5 +/- 6.3, 34.0 +/- 6.3, and 34.5 +/- 4.7 for thallium, MIBI, and tetrofosmin, respectively (P = .4), whereas mean summed difference scores were 1.9 +/- 2.6, 1.7 +/- 2.2, and 1.7 +/- 2.3, respectively (P = .9).
Conclusion: There were no significant differences between the tracers for the summed uptake scores. This suggests that the 3 tracers are comparable in clinical practice for assessing the extent and severity of perfusion abnormalities arising from mild to moderate coronary artery stenosis, especially in the presence of coexistent severe disease.
References: J Nucl Med. 1997 Jan;38(1):44-8. (PMID: 8998148)
J Am Coll Cardiol. 2001 Feb;37(2):458-62. (PMID: 11216963)
J Nucl Cardiol. 2001 Jul-Aug;8(4):482-98. (PMID: 11481571)
J Nucl Cardiol. 1996 May-Jun;3(3):194-203. (PMID: 8805739)
J Am Coll Cardiol. 1993 Sep;22(3):650-8. (PMID: 8354794)
Eur J Nucl Med Mol Imaging. 2002 Dec;29(12 ):1608-16. (PMID: 12458395)
Circulation. 2002 Jan 29;105(4):539-42. (PMID: 11815441)
J Am Coll Cardiol. 1986 Mar;7(3):464-71. (PMID: 3950226)
Circulation. 1993 Feb;87(2):345-54. (PMID: 8425283)
J Am Coll Cardiol. 1998 Feb;31(2):331-7. (PMID: 9462576)
Am J Cardiol. 1982 Jun;49(8):1917-26. (PMID: 7081072)
Circulation. 1995 Feb 1;91(3):813-20. (PMID: 7828310)
N Engl J Med. 1984 Mar 29;310(13):819-24. (PMID: 6700670)
N Engl J Med. 1994 Jun 23;330(25):1782-8. (PMID: 8190154)
Circulation. 1991 Nov;84(5):1984-92. (PMID: 1934373)
J Nucl Med. 1994 Apr;35(4):664-71. (PMID: 8151391)
Circulation. 1994 May;89(5):2150-60. (PMID: 8181140)
Circulation. 1990 Sep;82(3):998-1007. (PMID: 2394016)
Circulation. 1977 Aug;56(2):188-91. (PMID: 872309)
Circulation. 1990 Nov;82(5):1595-606. (PMID: 2225364)
Am J Cardiol. 1974 Jul;34(1):48-55. (PMID: 4835753)
J Am Coll Cardiol. 1992 Oct;20(4):979-85. (PMID: 1527310)
Circulation. 1996 Mar 1;93(5):905-14. (PMID: 8598081)
Circulation. 1997 Jul 15;96(2):484-90. (PMID: 9244216)
Circulation. 1997 Oct 7;96(7):2332-8. (PMID: 9337208)
J Am Coll Cardiol. 1994 Mar 15;23 (4):833-43. (PMID: 8106687)
Eur J Nucl Med. 1997 Oct;24(10 ):1230-6. (PMID: 9323263)
J Nucl Cardiol. 1994 Jan-Feb;1(1):57-64. (PMID: 9420671)
Heart. 2004 Aug;90 Suppl 5:v2-9. (PMID: 15254003)
J Am Coll Cardiol. 1990 Feb;15(2):318-29. (PMID: 2405036)
J Am Coll Cardiol. 1992 Dec;20(7):1612-25. (PMID: 1452936)
Circulation. 2005 Aug 30;112(9 Suppl):I311-6. (PMID: 16159837)
المشرفين على المادة: 0 (Organophosphorus Compounds)
0 (Organotechnetium Compounds)
0 (Radiopharmaceuticals)
37CB58V15B (thallium chloride)
42FOP1YX93 (technetium tc-99m tetrofosmin)
971Z4W1S09 (Technetium Tc 99m Sestamibi)
AD84R52XLF (Thallium)
تواريخ الأحداث: Date Created: 20060822 Date Completed: 20060912 Latest Revision: 20191210
رمز التحديث: 20240628
DOI: 10.1016/j.nuclcard.2006.03.018
PMID: 16919572
قاعدة البيانات: MEDLINE
الوصف
تدمد:1532-6551
DOI:10.1016/j.nuclcard.2006.03.018