دورية أكاديمية
Evaluation of a covered-rod silicone implant containing ivermectin for long-term prevention of heartworm infection in dogs.
| العنوان: | Evaluation of a covered-rod silicone implant containing ivermectin for long-term prevention of heartworm infection in dogs. |
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| المؤلفون: | Cunningham CP; Smart Drug Systems Inc, Ste 102, 181 S Broad St, Pawcatuck, CT 06379, USA., Brown JM, Jacobson GA, Brandon MR, Martinod SR |
| المصدر: | American journal of veterinary research [Am J Vet Res] 2006 Sep; Vol. 67 (9), pp. 1564-9. |
| نوع المنشور: | Evaluation Study; Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Veterinary Medical Association Country of Publication: United States NLM ID: 0375011 Publication Model: Print Cited Medium: Print ISSN: 0002-9645 (Print) Linking ISSN: 00029645 NLM ISO Abbreviation: Am J Vet Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Schaumburg, Ill. : American Veterinary Medical Association Original Publication: Chicago : American Veterinary Medical Assn. |
| مواضيع طبية MeSH: | Anthelmintics/*administration & dosage , Dirofilaria immitis/*growth & development , Dirofilariasis/*prevention & control , Dog Diseases/*parasitology , Dog Diseases/*prevention & control , Ivermectin/*administration & dosage, Animals ; Anthelmintics/blood ; Antigens, Helminth/blood ; Dirofilaria immitis/immunology ; Dirofilariasis/blood ; Dirofilariasis/parasitology ; Dog Diseases/blood ; Dogs ; Dose-Response Relationship, Drug ; Drug Implants ; Female ; Heart/parasitology ; Ivermectin/blood ; Lung/parasitology ; Male ; Silicones/administration & dosage |
| مستخلص: | Objective: To evaluate use of covered-rod (CR) silicone implants containing ivermectin for long-term prevention of infection with Dirofilaria immitisin dogs. Animals: 145 adult male and female dogs. Procedures: Dogs received implants of different sizes, and ivermectin concentrations and serum ivermectin concentrations were monitored for 16, 57, and 56 weeks, respectively, in 3 preclinical dose selection studies. Ability of implants to prevent infection with D immitis was evaluated in 2 further studies; dogs were challenged with 50 infective third-stage larvae 52 weeks after implant administration and necropsied 145 days after challenge, and the total number of adult heartworms was counted. A field study was then undertaken in which client-owned dogs received an implant and plasma samples were collected at intervals until week 52 for ivermectin analysis and heartworm antigen determination. Results: Use of the implants resulted in maintenance of an ivermectin concentration > or = 0.2 ng/mL for 12 months. In challenge studies, no treated dogs had adult heartworms, in contrast to untreated dogs, which all had adult heartworms at necropsy. In the field study, dogs treated with an implant had negative results of heartworm antigen testing for 12 months. Conclusions and Clinical Relevance: The CR silicone implant containing 7.3 mg of ivermectin was 100% effective in preventing experimental infection with D immitislarvae and resulted in negative results for heartworm antigen in a field trial. This product has the potential to alleviate poor owner compliance with monthly prevention regimens. |
| المشرفين على المادة: | 0 (Anthelmintics) 0 (Antigens, Helminth) 0 (Drug Implants) 0 (Silicones) 70288-86-7 (Ivermectin) |
| تواريخ الأحداث: | Date Created: 20060905 Date Completed: 20061017 Latest Revision: 20191210 |
| رمز التحديث: | 20240628 |
| DOI: | 10.2460/ajvr.67.9.1564 |
| PMID: | 16948602 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0002-9645 |
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| DOI: | 10.2460/ajvr.67.9.1564 |