دورية أكاديمية
[Serum NT-proBNP levels are a prognostic predictor in patients with advanced heart failure].
| العنوان: | [Serum NT-proBNP levels are a prognostic predictor in patients with advanced heart failure]. |
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| عنوان ترانسليتريتد: | O nível sérico de NT-proBNP é um preditor prognóstico em pacientes com insuficiência cardíaca avançada. |
| المؤلفون: | Pereira-Barretto AC; Instituto do Coração do Hospital das Clínicas, FMUSP, São Paulo, SP. pereira.barretto@incor.usp.br, de Oliveira MT Jr, Strunz CC, Del Carlo CH, Scipioni AR, Ramires JA |
| المصدر: | Arquivos brasileiros de cardiologia [Arq Bras Cardiol] 2006 Aug; Vol. 87 (2), pp. 174-7. |
| نوع المنشور: | English Abstract; Journal Article |
| اللغة: | Portuguese |
| بيانات الدورية: | Publisher: Sociedad Brasileira De Cardiologia Country of Publication: Brazil NLM ID: 0421031 Publication Model: Print Cited Medium: Print ISSN: 0066-782X (Print) Linking ISSN: 0066782X NLM ISO Abbreviation: Arq Bras Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Sao Paulo : Sociedad Brasileira De Cardiologia |
| مواضيع طبية MeSH: | Heart Failure/*blood , Natriuretic Peptide, Brain/*blood , Peptide Fragments/*blood, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Brazil/epidemiology ; Epidemiologic Methods ; Female ; Heart Failure/mortality ; Humans ; Male ; Middle Aged ; Prognosis |
| مستخلص: | Objective: To verify if the determination of NT-proBNP values would help predict the prognosis in advanced heart failure (HF) patients. Methods: One hundred and five subjects with average age of 52.4 years were evaluated, 66.6% of them males. Thirty-three (32.0%) subjects were outpatients and 70 (67.9%) were inpatients (functional class III/IV) admitted to the hospital for cardiac compensation. All patients had left ventricular systolic dysfunction and a mean ejection fraction of 0.29. The NT-proBNP levels were measured in all patients and they were followed-up over a period from 2 to 90 days (average 77 days). A ROC curve was drawn to determine the best cut-off point, as well as the corresponding Kaplan-Meyer survival curves. Results: During the follow-up period, 22 patients died. The average NT-proBNP value of the patients who remained alive was 6,443.67+/-6,071.62 pg/ml, whereas that of those who died was 14,609.66+/-12,165.15 pg/ml (p=0.001). The ROC curve identified a cut-off point at 6,000 pg/ml with 77.3% sensitivity (area under the curve: 0.74). The survival curve for values below and above 6,000 pg/ml was significantly different (p=0.002): patients with values below 6,000 pg/ml had a 90.2% 90-day survival, and those patients with values above, a 66% survival. Conclusion: Patients with advanced HF, especially those admitted to the hospital for cardiac compensation, had much higher NT-proBNP values, with a two-fold increase among those who died during the follow-up period. Values above 6,000 pg/ml identify the patients most likely to die within 90 days after hospital discharge. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Peptide Fragments) 0 (pro-brain natriuretic peptide (1-76)) 114471-18-0 (Natriuretic Peptide, Brain) |
| تواريخ الأحداث: | Date Created: 20060905 Date Completed: 20070322 Latest Revision: 20190606 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1590/s0066-782x2006001500016 |
| PMID: | 16951836 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0066-782X |
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| DOI: | 10.1590/s0066-782x2006001500016 |