دورية أكاديمية
The association between polymorphic genotypes of glutathione S-transferases and COPD in the Turkish population.
| العنوان: | The association between polymorphic genotypes of glutathione S-transferases and COPD in the Turkish population. |
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| المؤلفون: | Calikoglu M; Department of Chest Disease, Mersin University Faculty of Medicine, 33079 Mersin, Turkey. mukadder@mersin.edu.tr, Tamer L, Ates Aras N, Karakaş S, Ercan B |
| المصدر: | Biochemical genetics [Biochem Genet] 2006 Oct; Vol. 44 (7-8), pp. 307-19. Date of Electronic Publication: 2006 Sep 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-2928 (Print) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : New York : Kluwer Academic/Plenum Publishers Original Publication: New York, Plenum Press. |
| مواضيع طبية MeSH: | Genetic Predisposition to Disease* , Polymorphism, Genetic*, Glutathione Transferase/*genetics , Pulmonary Disease, Chronic Obstructive/*genetics, Aged ; Case-Control Studies ; Female ; Glutathione S-Transferase pi/genetics ; Humans ; Male ; Middle Aged ; Odds Ratio ; Smoking ; Turkey |
| مستخلص: | Although smoking is regarded as the most important causal factor in chronic obstructive pulmonary disease (COPD), only 10-20% of smokers develop symptomatic COPD, which indicates the presence of genetic predisposing factors in its pathogenesis. This study investigates the association between gene polymorphysims of glutathione S-transferases (GSTs) and COPD. Blood samples were taken from 149 patients and 150 healthy controls. Polymorphisms of GSTT1, GSTM1, and GSTP1 were genotyped using Real-Time PCR. Multivariate logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals between specific genotypes and COPD. There was no difference in the frequencies of the genotypes of GSTM1 and GSTT1 between the groups, but the GSTP1 Ile/Ile genotype was significantly higher in the patients than in the controls (61.1% vs. 38%). GSTP1 Ile/Val and Val/Val genotypes were associated with a decreased risk of COPD when compared to the Ile/Ile genotype (2.12-fold and 4-fold, respectively). Thus we suggest that the Val allele of GSTP1 may have a protective effect for development of COPD. Furthermore, when we evaluated the association between GSTP1 genes and smoking status, smokers with the GSTP1 Ile allele had an increased risk for the development of COPD. Among the combinations of the genotypes, the combination of GSTM1, GSTT1 null, and GSTP1 Val/Val was associated with the maximal increased risk (12-fold) of COPD. Thus to explain the ethiopathogenesis of COPD, investigation of a single gene family is inadequate. Based on our results and the previous data, further studies should be focused on the GSTP1 gene and the interactions with other genes such as polymorphisms of N-acetyltransferases, GSTM1 and GSTT1, microsomal epoxide hydrolase, and allelic variants of cytochrome P450. |
| المشرفين على المادة: | EC 2.5.1.- (glutathione S-transferase T1) EC 2.5.1.18 (Glutathione S-Transferase pi) EC 2.5.1.18 (Glutathione Transferase) EC 2.5.1.18 (glutathione S-transferase M1) |
| تواريخ الأحداث: | Date Created: 20060916 Date Completed: 20070621 Latest Revision: 20220310 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s10528-006-9031-4 |
| PMID: | 16977512 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-2928 |
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| DOI: | 10.1007/s10528-006-9031-4 |