دورية أكاديمية
Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. chinensis (Haw.) Berg.
| العنوان: | Macrophage activation by polysaccharide biological response modifier isolated from Aloe vera L. var. chinensis (Haw.) Berg. |
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| المؤلفون: | Liu C; Department of Biochemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, People's Republic of China., Leung MY, Koon JC, Zhu LF, Hui YZ, Yu B, Fung KP |
| المصدر: | International immunopharmacology [Int Immunopharmacol] 2006 Nov; Vol. 6 (11), pp. 1634-41. Date of Electronic Publication: 2006 May 22. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1567-5769 (Print) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2001- |
| مواضيع طبية MeSH: | Aloe*/chemistry, Antineoplastic Agents/*pharmacology , Immunologic Factors/*pharmacology , Macrophage Activation/*drug effects , Polysaccharides/*pharmacology, Animals ; Cell Line, Tumor ; Histocompatibility Antigens Class II/biosynthesis ; Immunologic Factors/isolation & purification ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/immunology ; Macrophages, Peritoneal/metabolism ; Mice ; Mice, Inbred BALB C ; Nitric Oxide/biosynthesis ; Phagocytosis/drug effects ; Polysaccharides/isolation & purification ; Receptors, IgG/biosynthesis ; Tumor Necrosis Factor-alpha/biosynthesis |
| مستخلص: | A mannose-rich polysaccharide biological response modifier (BRM), derived from Aloe vera L. var. chinensis (Haw.) Berg., was demonstrated to be a potent murine B- and T-cell stimulator in our previous study. We here report the stimulatory activity of PAC-I on murine peritoneal macrophage. The polysaccharide when injected into mice enhanced the migration of macrophages to the peritoneal cavity. Peritoneal macrophage when treated by PAC-I in vitro had increased expression of MHC-II and FcgammaR, and enhanced endocytosis, phagocytosis, nitric oxide production, TNF-alpha secretion and tumor cell cytotoxicity. The administration of PAC-I into allogeneic ICR mice stimulated systemic TNF-alpha production in a dose-dependent manner and prolonged the survival of tumor-bearing mice. PAC-I is thus a potent stimulator of murine macrophage and the in vitro observed tumoricidal properties of activated macrophage might account for the in vivo antitumor properties of PAC-I. Our research findings may have therapeutic implications in tumor immunotherapy. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Histocompatibility Antigens Class II) 0 (Immunologic Factors) 0 (Polysaccharides) 0 (Receptors, IgG) 0 (Tumor Necrosis Factor-alpha) 31C4KY9ESH (Nitric Oxide) |
| تواريخ الأحداث: | Date Created: 20060919 Date Completed: 20061213 Latest Revision: 20131121 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.intimp.2006.04.013 |
| PMID: | 16979117 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1567-5769 |
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| DOI: | 10.1016/j.intimp.2006.04.013 |