دورية أكاديمية
Pesticides may be altering constitutive nitric oxide release, thereby compromising health.
| العنوان: | Pesticides may be altering constitutive nitric oxide release, thereby compromising health. |
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| المؤلفون: | Casares FM; Marine Sciences Research Center, Stony Brook University, Stony Brook, New York, USA. fcasares@sunynri.org, Mantione K |
| المصدر: | Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2006 Oct; Vol. 12 (10), pp. RA235-40. Date of Electronic Publication: 2006 Sep 25. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: International Scientific Information, Inc Country of Publication: United States NLM ID: 9609063 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1234-1010 (Print) Linking ISSN: 12341010 NLM ISO Abbreviation: Med Sci Monit Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Smithtown, NY : International Scientific Information, Inc. Original Publication: Warsaw, Poland : Medical Science International |
| مواضيع طبية MeSH: | Health* , Models, Biological*, Nitric Oxide/*metabolism , Pesticides/*toxicity, Animals ; Calcium/metabolism ; Environmental Pollutants/toxicity ; Hydrocarbons, Chlorinated/toxicity ; Immune System/drug effects ; Nervous System Physiological Phenomena/drug effects ; Nitric Oxide Synthase Type I/genetics ; Nitric Oxide Synthase Type I/metabolism ; Nitric Oxide Synthase Type II/genetics ; Nitric Oxide Synthase Type II/metabolism ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Organophosphates/toxicity ; Pyrethrins/toxicity |
| مستخلص: | Numerous studies, focusing on the effects of environmental pollutants such as pyrethroids, organochlorines, organophosphate pesticides, etc, appear to affect intracellular ion balance, particularly calcium. We speculate that these chemicals may specifically target constitutive nitric oxide synthase (cNOS)-mediated processes, e.g., immune. The alteration of intracellular Ca2+ transients by these pollutants may represent an important common mechanism responsible for the abrogation of cNOS activation. Moreover, one can hypothesize that exposure to sublethal levels of pesticides that alter calcium transients, could potentially lead to immune, neural and vascular dysfunction in animals. This may be especially true for marine organisms that can be found close to shore and in estuaries, which are more likely to be exposed to these compounds resulting from riverine and other inputs. |
| Number of References: | 82 |
| المشرفين على المادة: | 0 (Environmental Pollutants) 0 (Hydrocarbons, Chlorinated) 0 (Organophosphates) 0 (Pesticides) 0 (Pyrethrins) 31C4KY9ESH (Nitric Oxide) EC 1.14.13.39 (Nitric Oxide Synthase Type I) EC 1.14.13.39 (Nitric Oxide Synthase Type II) EC 1.14.13.39 (Nitric Oxide Synthase Type III) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 20060929 Date Completed: 20061213 Latest Revision: 20181201 |
| رمز التحديث: | 20231215 |
| PMID: | 17006416 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1234-1010 |
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