دورية أكاديمية
Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings.
| العنوان: | Preceding immunosuppressive therapy with antithymocyte globulin and ciclosporin increases the incidence of graft rejection in children with aplastic anaemia who underwent allogeneic bone marrow transplantation from HLA-identical siblings. |
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| المؤلفون: | Kobayashi R; Department of Paediatrics, Hokkaido University Graduate School of Medicine, Sapporo, Japan. r-koba@med.hokudai.ac.jp, Yabe H, Hara J, Morimoto A, Tsuchida M, Mugishima H, Ohara A, Tsukimoto I, Kato K, Kigasawa H, Tabuchi K, Nakahata T, Ohga S, Kojima S |
| مؤلفون مشاركون: | Japan Childhood Aplastic Anemia Study Group |
| المصدر: | British journal of haematology [Br J Haematol] 2006 Dec; Vol. 135 (5), pp. 693-6. Date of Electronic Publication: 2006 Oct 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0007-1048 (Print) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Wiley-Blackwell Original Publication: Oxford : Blackwell Scientific Publications |
| مواضيع طبية MeSH: | Bone Marrow Transplantation* , Graft Rejection*, Anemia, Aplastic/*therapy , Antilymphocyte Serum/*administration & dosage , Antineoplastic Agents/*therapeutic use , Cyclosporine/*therapeutic use, Adolescent ; Anemia, Aplastic/drug therapy ; Anemia, Aplastic/immunology ; Child ; Child, Preschool ; Female ; Humans ; Incidence ; Infant ; Infant, Newborn ; Male ; Risk Factors ; Siblings ; Statistics, Nonparametric ; Survival Rate ; Transplantation Conditioning ; Transplantation, Isogeneic ; Treatment Failure |
| مستخلص: | The incidence of graft rejection was determined in 66 children with acquired aplastic anaemia (AA) following bone marrow transplantation (BMT) from a related donor. Eleven of 65 evaluable patients experienced either early or late rejection. Multivariate analysis identified previous immunosuppressive therapy with antithymocyte-globulin (ATG) and ciclosporin (CsA) as a risk factor for graft rejection (relative risk: 16.6, P = 0.001). Patients who received ATG and CsA had a significantly lower probability of failure-free survival than those who did not (69.7 +/- 6.2% vs. 87.9 +/- 8.0%, P = 0.044). These results suggest that BMT should be instituted immediately in children with severe AA who have human leucocyte antigen-identical siblings. |
| المشرفين على المادة: | 0 (Antilymphocyte Serum) 0 (Antineoplastic Agents) 83HN0GTJ6D (Cyclosporine) |
| تواريخ الأحداث: | Date Created: 20061014 Date Completed: 20070308 Latest Revision: 20131121 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1111/j.1365-2141.2006.06352.x |
| PMID: | 17038001 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0007-1048 |
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| DOI: | 10.1111/j.1365-2141.2006.06352.x |