دورية أكاديمية
A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis.
| العنوان: | A housekeeper with power of attorney: the rRNA genes in ribosome biogenesis. |
|---|---|
| المؤلفون: | Moss T; Cancer Research Centre and Department of Medical Biology, Laval University, CHUQ-HDQ, Pavillon St Patrick, 9 rue McMahon, Québec G1R 3S3, Canada. Tom.Moss@crhdq.ulaval.ca, Langlois F, Gagnon-Kugler T, Stefanovsky V |
| المصدر: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2007 Jan; Vol. 64 (1), pp. 29-49. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print Cited Medium: Print ISSN: 1420-682X (Print) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Basel : Springer Original Publication: Basel ; Boston : Birkhauser, c1997- |
| مواضيع طبية MeSH: | Gene Expression Regulation* , Genes, rRNA*, RNA, Ribosomal/*biosynthesis , Ribosomes/*metabolism, Animals ; Base Sequence ; Humans ; Molecular Sequence Data ; Protein Biosynthesis ; RNA Polymerase I/metabolism ; RNA, Ribosomal/chemistry ; Ribosomes/genetics ; Transcription, Genetic |
| مستخلص: | Ribosome biogenesis centres both physically and functionally on the activity of the ribosomal RNA (rRNA) genes. Ribosome assembly occurs co-transcriptionally on these genes, requires the coordinated expression and assembly of many hundreds of proteins and is finely tuned to cell and organism growth. This review presents contemporary understanding of the mode and the means of rRNA gene transcription and how growth factors, oncogenes and tumour suppressors regulate this transcription. It is argued that transcription elongation is a key mechanism regulating rRNA gene transcription. This unorthodox view provides a logical framework to explain the co-transcriptional phase of ribosome biogenesis. |
| Number of References: | 243 |
| المشرفين على المادة: | 0 (RNA, Ribosomal) EC 2.7.7.6 (RNA Polymerase I) |
| تواريخ الأحداث: | Date Created: 20061216 Date Completed: 20070223 Latest Revision: 20240531 |
| رمز التحديث: | 20240531 |
| مُعرف محوري في PubMed: | PMC11136161 |
| DOI: | 10.1007/s00018-006-6278-1 |
| PMID: | 17171232 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1420-682X |
|---|---|
| DOI: | 10.1007/s00018-006-6278-1 |