دورية أكاديمية
Long-lasting bioresorbable poly(lactic acid) (PLA94) mesh: a new approach for soft tissue reinforcement based on an experimental pilot study.
| العنوان: | Long-lasting bioresorbable poly(lactic acid) (PLA94) mesh: a new approach for soft tissue reinforcement based on an experimental pilot study. |
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| المؤلفون: | de Tayrac R; Obstetrics and Gynaecology Department, Carémeau University Hospital, Nimes, France. renaud.detayrac@chu-nimes.fr, Oliva-Lauraire MC, Guiraud I, Henry L, Vert M, Mares P |
| المصدر: | International urogynecology journal and pelvic floor dysfunction [Int Urogynecol J Pelvic Floor Dysfunct] 2007 Sep; Vol. 18 (9), pp. 1007-14. Date of Electronic Publication: 2007 Jan 09. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag London Ltd Country of Publication: England NLM ID: 9514583 Publication Model: Print-Electronic Cited Medium: Print NLM ISO Abbreviation: Int Urogynecol J Pelvic Floor Dysfunct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Surrey, UK : Springer-Verlag London Ltd., c1995- |
| مواضيع طبية MeSH: | Absorbable Implants* , Surgical Mesh*, Abdominal Wall/*surgery , Lactic Acid/*therapeutic use , Polyglycolic Acid/*therapeutic use , Polymers/*therapeutic use, Animals ; Collagen/metabolism ; Disease Models, Animal ; Female ; Pilot Projects ; Polyesters ; Rats ; Rats, Wistar ; Uterine Prolapse/surgery |
| مستخلص: | The purpose of this study was to evaluate host response and soft-tissue regeneration after poly(lactic acid) (PLA) mesh implantation in a rat model, in comparison with light-weight polypropylene (PPL) and poly(glycolic acid) (PGA) meshes. Full-thickness abdominal wall defects were created in 45 Wistar rats and reconstructed with 15 PLA(94), 15 PPL and 15 PGA meshes. Animals were killed on days 7, 30 and 90 to evaluate the presence of adhesions and changes in tensile strength of the implants. Histopathology and immunohistochemistry were performed to evaluate the collagen deposition and the inflammatory response. Statistics were done using unpaired Student's t-test, Mann-Whitney rank sum test, Student-Newman-Keuls test and Bonferroni (Dunn) t-test. The inflammatory response induced by the PLA mesh implantation was significantly milder than after PPL mesh. In PLA, vascularity and collagen organization was significantly higher than in PPL and PGA at 30 and 90 days, and collagen composition score was significantly higher than in PPL at 7 and 30 days. In PLA, shrinkage was significantly lower than in PPL and PGA at 7 and 30 days. Elongation at break and tensile strength were comparable between PLA and PPL over the 90-day period. The PLA mesh induces a milder inflammatory response, more orderly collagen deposition than PPL, and preserved comparable tensile strength after 90 days. |
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| المشرفين على المادة: | 0 (Polyesters) 0 (Polymers) 26009-03-0 (Polyglycolic Acid) 33X04XA5AT (Lactic Acid) 459TN2L5F5 (poly(lactide)) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20070111 Date Completed: 20071105 Latest Revision: 20181113 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00192-006-0270-z |
| PMID: | 17211529 |
| قاعدة البيانات: | MEDLINE |
| DOI: | 10.1007/s00192-006-0270-z |
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